Chen Y - Search Results

1

Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.

Shi-Wen X, Renzoni EA, Kennedy L, Howat S, Chen Y, Pearson JD, Bou-Gharios G, Dashwood MR, du Bois RM, Black CM, Denton CP, Abraham DJ, Leask A. Shi-Wen X, et al. Among authors: chen y. Matrix Biol. 2007 Oct;26(8):625-32. doi: 10.1016/j.matbio.2007.06.003. Epub 2007 Jun 18. Matrix Biol. 2007. PMID: 17681742

2

Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

Shi-Wen X, Chen Y, Denton CP, Eastwood M, Renzoni EA, Bou-Gharios G, Pearson JD, Dashwood M, du Bois RM, Black CM, Leask A, Abraham DJ. Shi-Wen X, et al. Among authors: chen y. Mol Biol Cell. 2004 Jun;15(6):2707-19. doi: 10.1091/mbc.e03-12-0902. Epub 2004 Mar 26. Mol Biol Cell. 2004. PMID: 15047866 Free PMC article.

3

CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin.

Chen Y, Abraham DJ, Shi-Wen X, Pearson JD, Black CM, Lyons KM, Leask A. Chen Y, et al. Mol Biol Cell. 2004 Dec;15(12):5635-46. doi: 10.1091/mbc.e04-06-0490. Epub 2004 Sep 15. Mol Biol Cell. 2004. PMID: 15371538 Free PMC article.

4

Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.

Chen Y, Shi-Wen X, van Beek J, Kennedy L, McLeod M, Renzoni EA, Bou-Gharios G, Wilcox-Adelman S, Goetinck PF, Eastwood M, Black CM, Abraham DJ, Leask A. Chen Y, et al. Am J Pathol. 2005 Dec;167(6):1699-711. doi: 10.1016/s0002-9440(10)61252-7. Am J Pathol. 2005. PMID: 16314481 Free PMC article.

5

CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.

Shi-wen X, Stanton LA, Kennedy L, Pala D, Chen Y, Howat SL, Renzoni EA, Carter DE, Bou-Gharios G, Stratton RJ, Pearson JD, Beier F, Lyons KM, Black CM, Abraham DJ, Leask A. Shi-wen X, et al. Among authors: chen y. J Biol Chem. 2006 Apr 21;281(16):10715-26. doi: 10.1074/jbc.M511343200. Epub 2006 Feb 16. J Biol Chem. 2006. PMID: 16484225 Free article.

6

Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts.

Chen Y, Shi-wen X, Eastwood M, Black CM, Denton CP, Leask A, Abraham DJ. Chen Y, et al. Arthritis Rheum. 2006 Apr;54(4):1309-16. doi: 10.1002/art.21725. Arthritis Rheum. 2006. PMID: 16575856 Free article.

7

Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts.

Chen Y, Leask A, Abraham DJ, Pala D, Shiwen X, Khan K, Liu S, Carter DE, Wilcox-Adelman S, Goetinck P, Denton CP, Black CM, Pitsillides AA, Sarraf CE, Eastwood M. Chen Y, et al. Arthritis Rheum. 2008 Feb;58(2):577-85. doi: 10.1002/art.23146. Arthritis Rheum. 2008. PMID: 18240216 Free article.

8

CCN2 is necessary for the function of mouse embryonic fibroblasts.

Kennedy L, Liu S, Shi-Wen X, Chen Y, Eastwood M, Sabetkar M, Carter DE, Lyons KM, Black CM, Abraham DJ, Leask A. Kennedy L, et al. Among authors: chen y. Exp Cell Res. 2007 Mar 10;313(5):952-64. doi: 10.1016/j.yexcr.2006.12.006. Epub 2006 Dec 23. Exp Cell Res. 2007. PMID: 17239853

9

FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype.

Liu S, Xu SW, Kennedy L, Pala D, Chen Y, Eastwood M, Carter DE, Black CM, Abraham DJ, Leask A. Liu S, et al. Among authors: chen y. Mol Biol Cell. 2007 Jun;18(6):2169-78. doi: 10.1091/mbc.e06-12-1121. Epub 2007 Apr 4. Mol Biol Cell. 2007. PMID: 17409352 Free PMC article.

10

Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing.

Denton CP, Khan K, Hoyles RK, Shiwen X, Leoni P, Chen Y, Eastwood M, Abraham DJ. Denton CP, et al. Among authors: chen y. J Invest Dermatol. 2009 Jan;129(1):194-204. doi: 10.1038/jid.2008.171. Epub 2008 Jun 19. J Invest Dermatol. 2009. PMID: 18563179 Free article.

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