Leaney J - Search Results

1

Impact of study design on proarrhythmia prediction in the SCREENIT rabbit isolated heart model.

Steidl-Nichols JV, Hanton G, Leaney J, Liu RC, Leishman D, McHarg A, Wallis R. Steidl-Nichols JV, et al. Among authors: leaney j. J Pharmacol Toxicol Methods. 2008 Jan-Feb;57(1):9-22. doi: 10.1016/j.vascn.2007.06.003. Epub 2007 Jul 3. J Pharmacol Toxicol Methods. 2008. PMID: 17707659

2

Towards automation of a valuable preclinical cardiac safety pharmacology assay: Evaluation of the effects of cardiac ion channel blockers on cardiac repolarisation in vitro.

Lightbown ID, Johnson M, Davis A, Leaney J, Leishman DJ. Lightbown ID, et al. Among authors: leaney j. J Pharmacol Toxicol Methods. 2007 Sep-Oct;56(2):194-202. doi: 10.1016/j.vascn.2007.03.008. Epub 2007 May 24. J Pharmacol Toxicol Methods. 2007. PMID: 17583537

3

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide.

Milnes JT, Witchel HJ, Leaney JL, Leishman DJ, Hancox JC. Milnes JT, et al. Among authors: leaney jl. J Pharmacol Toxicol Methods. 2010 Mar-Apr;61(2):178-91. doi: 10.1016/j.vascn.2010.02.007. Epub 2010 Feb 19. J Pharmacol Toxicol Methods. 2010. PMID: 20172036

4

Mechanism of hERG K+ channel blockade by the fluoroquinolone antibiotic moxifloxacin.

Alexandrou AJ, Duncan RS, Sullivan A, Hancox JC, Leishman DJ, Witchel HJ, Leaney JL. Alexandrou AJ, et al. Among authors: leaney jl. Br J Pharmacol. 2006 Apr;147(8):905-16. doi: 10.1038/sj.bjp.0706678. Br J Pharmacol. 2006. PMID: 16474415 Free PMC article.

5

hERG K+ channel blockade by the antipsychotic drug thioridazine: An obligatory role for the S6 helix residue F656.

Milnes JT, Witchel HJ, Leaney JL, Leishman DJ, Hancox JC. Milnes JT, et al. Among authors: leaney jl. Biochem Biophys Res Commun. 2006 Dec 8;351(1):273-80. doi: 10.1016/j.bbrc.2006.10.039. Epub 2006 Oct 23. Biochem Biophys Res Commun. 2006. PMID: 17056009

6

Erythromycin block of the HERG K+ channel: accessibility to F656 and Y652.

Duncan RS, Ridley JM, Dempsey CE, Leishman DJ, Leaney JL, Hancox JC, Witchel HJ. Duncan RS, et al. Among authors: leaney jl. Biochem Biophys Res Commun. 2006 Mar 10;341(2):500-6. doi: 10.1016/j.bbrc.2006.01.008. Epub 2006 Jan 13. Biochem Biophys Res Commun. 2006. PMID: 16446155

7

Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin.

Duncan RS, McPate MJ, Ridley JM, Gao Z, James AF, Leishman DJ, Leaney JL, Witchel HJ, Hancox JC. Duncan RS, et al. Among authors: leaney jl. Biochem Pharmacol. 2007 Aug 1;74(3):425-37. doi: 10.1016/j.bcp.2007.04.024. Epub 2007 May 3. Biochem Pharmacol. 2007. PMID: 17560554 Free PMC article.

8

Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs.

Perry M, Stansfeld PJ, Leaney J, Wood C, de Groot MJ, Leishman D, Sutcliffe MJ, Mitcheson JS. Perry M, et al. Among authors: leaney j. Mol Pharmacol. 2006 Feb;69(2):509-19. doi: 10.1124/mol.105.016741. Epub 2005 Nov 16. Mol Pharmacol. 2006. PMID: 16291873

9

The human ether-a'-go-go related gene (hERG) K+ channel blockade by the investigative selective-serotonin reuptake inhibitor CONA-437: limited dependence on S6 aromatic residues.

Alexandrou AJ, Milnes JT, Sun SZ, Fermini B, Kim SC, Jenkinson S, Leishman DJ, Witchel HJ, Hancox JC, Leaney JL. Alexandrou AJ, et al. Among authors: leaney jl. J Physiol Pharmacol. 2014 Aug;65(4):511-23. J Physiol Pharmacol. 2014. PMID: 25179083 Free article.

10

The dynamics of formation and action of the ternary complex revealed in living cells using a G-protein-gated K+ channel as a biosensor.

Benians A, Leaney JL, Milligan G, Tinker A. Benians A, et al. J Biol Chem. 2003 Mar 21;278(12):10851-8. doi: 10.1074/jbc.M212299200. Epub 2003 Jan 14. J Biol Chem. 2003. PMID: 12529316 Free article.

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