Demuth HU - Search Results

1

Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor.

Parthier C, Kleinschmidt M, Neumann P, Rudolph R, Manhart S, Schlenzig D, Fanghänel J, Rahfeld JU, Demuth HU, Stubbs MT. Parthier C, et al. Among authors: demuth hu. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):13942-7. doi: 10.1073/pnas.0706404104. Epub 2007 Aug 21. Proc Natl Acad Sci U S A. 2007. PMID: 17715056 Free PMC article.

2

Structures of glycosylated mammalian glutaminyl cyclases reveal conformational variability near the active center.

Ruiz-Carrillo D, Koch B, Parthier C, Wermann M, Dambe T, Buchholz M, Ludwig HH, Heiser U, Rahfeld JU, Stubbs MT, Schilling S, Demuth HU. Ruiz-Carrillo D, et al. Among authors: demuth hu. Biochemistry. 2011 Jul 19;50(28):6280-8. doi: 10.1021/bi200249h. Epub 2011 Jun 27. Biochemistry. 2011. PMID: 21671571

3

Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs.

Koch B, Kolenko P, Buchholz M, Carrillo DR, Parthier C, Wermann M, Rahfeld JU, Reuter G, Schilling S, Stubbs MT, Demuth HU. Koch B, et al. Among authors: demuth hu. Biochemistry. 2012 Sep 18;51(37):7383-92. doi: 10.1021/bi300687g. Epub 2012 Sep 5. Biochemistry. 2012. PMID: 22897232

4

Structure-function analysis of a series of novel GIP analogues containing different helical length linkers.

Manhart S, Hinke SA, McIntosh CH, Pederson RA, Demuth HU. Manhart S, et al. Among authors: demuth hu. Biochemistry. 2003 Mar 18;42(10):3081-8. doi: 10.1021/bi026868e. Biochemistry. 2003. PMID: 12627975

5

Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides.

Schlenzig D, Manhart S, Cinar Y, Kleinschmidt M, Hause G, Willbold D, Funke SA, Schilling S, Demuth HU. Schlenzig D, et al. Among authors: demuth hu. Biochemistry. 2009 Jul 28;48(29):7072-8. doi: 10.1021/bi900818a. Biochemistry. 2009. PMID: 19518051

6

Kinetic and structural characterization of bacterial glutaminyl cyclases from Zymomonas mobilis and Myxococcus xanthus.

Carrillo DR, Parthier C, Jänckel N, Grandke J, Stelter M, Schilling S, Boehme M, Neumann P, Wolf R, Demuth HU, Stubbs MT, Rahfeld JU. Carrillo DR, et al. Among authors: demuth hu. Biol Chem. 2010 Dec;391(12):1419-28. doi: 10.1515/BC.2010.130. Biol Chem. 2010. PMID: 20868223

7

Structural and functional analyses of pyroglutamate-amyloid-β-specific antibodies as a basis for Alzheimer immunotherapy.

Piechotta A, Parthier C, Kleinschmidt M, Gnoth K, Pillot T, Lues I, Demuth HU, Schilling S, Rahfeld JU, Stubbs MT. Piechotta A, et al. Among authors: demuth hu. J Biol Chem. 2017 Jul 28;292(30):12713-12724. doi: 10.1074/jbc.M117.777839. Epub 2017 Jun 16. J Biol Chem. 2017. PMID: 28623233 Free PMC article.

8

Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis.

Taudte N, Linnert M, Rahfeld JU, Piechotta A, Ramsbeck D, Buchholz M, Kolenko P, Parthier C, Houston JA, Veillard F, Eick S, Potempa J, Schilling S, Demuth HU, Stubbs MT. Taudte N, et al. Among authors: demuth hu. J Biol Chem. 2021 Jan-Jun;296:100263. doi: 10.1016/j.jbc.2021.100263. Epub 2021 Jan 8. J Biol Chem. 2021. PMID: 33837744 Free PMC article.

9

Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor.

Linnert M, Fritz C, Jäger C, Schlenzig D, Ramsbeck D, Kleinschmidt M, Wermann M, Demuth HU, Parthier C, Schilling S. Linnert M, et al. Among authors: demuth hu. Int J Mol Sci. 2021 May 26;22(11):5651. doi: 10.3390/ijms22115651. Int J Mol Sci. 2021. PMID: 34073350 Free PMC article.

10

Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.

Engel M, Hoffmann T, Manhart S, Heiser U, Chambre S, Huber R, Demuth HU, Bode W. Engel M, et al. Among authors: demuth hu. J Mol Biol. 2006 Jan 27;355(4):768-83. doi: 10.1016/j.jmb.2005.11.014. Epub 2005 Nov 22. J Mol Biol. 2006. PMID: 16330047

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