McLean GW - Search Results

1

Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex.

Serrels B, Serrels A, Brunton VG, Holt M, McLean GW, Gray CH, Jones GE, Frame MC. Serrels B, et al. Among authors: mclean gw. Nat Cell Biol. 2007 Sep;9(9):1046-56. doi: 10.1038/ncb1626. Epub 2007 Aug 26. Nat Cell Biol. 2007. PMID: 17721515

2

Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling.

Avizienyte E, Wyke AW, Jones RJ, McLean GW, Westhoff MA, Brunton VG, Frame MC. Avizienyte E, et al. Among authors: mclean gw. Nat Cell Biol. 2002 Aug;4(8):632-8. doi: 10.1038/ncb829. Nat Cell Biol. 2002. PMID: 12134161

3

Focal adhesion kinase as a potential target in oncology.

McLean GW, Avizienyte E, Frame MC. McLean GW, et al. Expert Opin Pharmacother. 2003 Feb;4(2):227-34. doi: 10.1517/14656566.4.2.227. Expert Opin Pharmacother. 2003. PMID: 12562313 Review.

4

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.

McLean GW, Carragher NO, Avizienyte E, Evans J, Brunton VG, Frame MC. McLean GW, et al. Nat Rev Cancer. 2005 Jul;5(7):505-15. doi: 10.1038/nrc1647. Nat Rev Cancer. 2005. PMID: 16069815 Review.

5

v-Src induces tyrosine phosphorylation of focal adhesion kinase independently of tyrosine 397 and formation of a complex with Src.

McLean GW, Fincham VJ, Frame MC. McLean GW, et al. J Biol Chem. 2000 Jul 28;275(30):23333-9. doi: 10.1074/jbc.M909322199. J Biol Chem. 2000. PMID: 10816598 Free article.

6

The protrusive phase and full development of integrin-dependent adhesions in colon epithelial cells require FAK- and ERK-mediated actin spike formation: deregulation in cancer cells.

Brunton VG, Fincham VJ, McLean GW, Winder SJ, Paraskeva C, Marshall JF, Frame MC. Brunton VG, et al. Among authors: mclean gw. Neoplasia. 2001 May-Jun;3(3):215-26. doi: 10.1038/sj.neo.7900149. Neoplasia. 2001. PMID: 11494115 Free PMC article.

7

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

McLean GW, Komiyama NH, Serrels B, Asano H, Reynolds L, Conti F, Hodivala-Dilke K, Metzger D, Chambon P, Grant SG, Frame MC. McLean GW, et al. Genes Dev. 2004 Dec 15;18(24):2998-3003. doi: 10.1101/gad.316304. Genes Dev. 2004. PMID: 15601818 Free PMC article.

8

The catalytic activity of the Src family kinases is required to disrupt cadherin-dependent cell-cell contacts.

Owens DW, McLean GW, Wyke AW, Paraskeva C, Parkinson EK, Frame MC, Brunton VG. Owens DW, et al. Among authors: mclean gw. Mol Biol Cell. 2000 Jan;11(1):51-64. doi: 10.1091/mbc.11.1.51. Mol Biol Cell. 2000. PMID: 10637290 Free PMC article.

9

Decreased focal adhesion kinase suppresses papilloma formation during experimental mouse skin carcinogenesis.

McLean GW, Brown K, Arbuckle MI, Wyke AW, Pikkarainen T, Ruoslahti E, Frame MC. McLean GW, et al. Cancer Res. 2001 Dec 1;61(23):8385-9. Cancer Res. 2001. PMID: 11731413

10

Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression.

Lahlou H, Sanguin-Gendreau V, Zuo D, Cardiff RD, McLean GW, Frame MC, Muller WJ. Lahlou H, et al. Among authors: mclean gw. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20302-7. doi: 10.1073/pnas.0710091104. Epub 2007 Dec 3. Proc Natl Acad Sci U S A. 2007. PMID: 18056629 Free PMC article.

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