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Structure-activity relationship study of novel NR2B-selective antagonists with arylamides to avoid reactive metabolites formation.
Kawai M, Sakurada I, Morita A, Iwamuro Y, Ando K, Omura H, Sakakibara S, Masuda T, Koike H, Honma T, Hattori K, Takashima T, Mizuno K, Mizutani M, Kawamura M. Kawai M, et al. Among authors: mizutani m. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5537-42. doi: 10.1016/j.bmcl.2007.08.033. Epub 2007 Aug 19. Bioorg Med Chem Lett. 2007. PMID: 17766107
Discovery of (-)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone--a potent NR2B-selective N-methyl D-aspartate (NMDA) antagonist for the treatment of pain.
Kawai M, Ando K, Matsumoto Y, Sakurada I, Hirota M, Nakamura H, Ohta A, Sudo M, Hattori K, Takashima T, Hizue M, Watanabe S, Fujita I, Mizutani M, Kawamura M. Kawai M, et al. Among authors: mizutani m. Bioorg Med Chem Lett. 2007 Oct 15;17(20):5558-62. doi: 10.1016/j.bmcl.2007.08.014. Epub 2007 Aug 15. Bioorg Med Chem Lett. 2007. PMID: 17766106
Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist 'CJ-17,493'.
Shishido Y, Wakabayashi H, Koike H, Ueno N, Nukui S, Yamagishi T, Murata Y, Naganeo F, Mizutani M, Shimada K, Fujiwara Y, Sakakibara A, Suga O, Kusano R, Ueda S, Kanai Y, Tsuchiya M, Satake K. Shishido Y, et al. Among authors: mizutani m. Bioorg Med Chem. 2008 Aug 1;16(15):7193-205. doi: 10.1016/j.bmc.2008.06.047. Epub 2008 Jun 26. Bioorg Med Chem. 2008. PMID: 18640044
894 results