Patterson AW - Search Results

1

Design, synthesis, and biological properties of highly potent tubulysin D analogues.

Patterson AW, Peltier HM, Sasse F, Ellman JA. Patterson AW, et al. Chemistry. 2007;13(34):9534-41. doi: 10.1002/chem.200701057. Chemistry. 2007. PMID: 17828721

2

The total synthesis of tubulysin D.

Peltier HM, McMahon JP, Patterson AW, Ellman JA. Peltier HM, et al. Among authors: patterson aw. J Am Chem Soc. 2006 Dec 20;128(50):16018-9. doi: 10.1021/ja067177z. J Am Chem Soc. 2006. PMID: 17165738

3

Expedient synthesis of N-methyl tubulysin analogues with high cytotoxicity.

Patterson AW, Peltier HM, Ellman JA. Patterson AW, et al. J Org Chem. 2008 Jun 20;73(12):4362-9. doi: 10.1021/jo800384x. Epub 2008 May 15. J Org Chem. 2008. PMID: 18479168

4

Substrate activity screening: a fragment-based method for the rapid identification of nonpeptidic protease inhibitors.

Wood WJ, Patterson AW, Tsuruoka H, Jain RK, Ellman JA. Wood WJ, et al. Among authors: patterson aw. J Am Chem Soc. 2005 Nov 9;127(44):15521-7. doi: 10.1021/ja0547230. J Am Chem Soc. 2005. PMID: 16262416

5

Asymmetric synthesis of alpha,alpha-dibranched propargylamines by acetylide additions to N-tert-butanesulfinyl ketimines.

Patterson AW, Ellman JA. Patterson AW, et al. J Org Chem. 2006 Sep 1;71(18):7110-2. doi: 10.1021/jo061160h. J Org Chem. 2006. PMID: 16930078

6

Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method.

Patterson AW, Wood WJ, Hornsby M, Lesley S, Spraggon G, Ellman JA. Patterson AW, et al. J Med Chem. 2006 Oct 19;49(21):6298-307. doi: 10.1021/jm060701s. J Med Chem. 2006. PMID: 17034136

7

Substrate activity screening (SAS): a general procedure for the preparation and screening of a fragment-based non-peptidic protease substrate library for inhibitor discovery.

Patterson AW, Wood WJ, Ellman JA. Patterson AW, et al. Nat Protoc. 2007;2(2):424-33. doi: 10.1038/nprot.2007.28. Nat Protoc. 2007. PMID: 17406604

8

Chemotherapeutic evaluation of a synthetic tubulysin analogue-dendrimer conjugate in c26 tumor bearing mice.

Floyd WC 3rd, Datta GK, Imamura S, Kieler-Ferguson HM, Jerger K, Patterson AW, Fox ME, Szoka FC, Fréchet JM, Ellman JA. Floyd WC 3rd, et al. Among authors: patterson aw. ChemMedChem. 2011 Jan 3;6(1):49-53. doi: 10.1002/cmdc.201000377. ChemMedChem. 2011. PMID: 20973119 Free PMC article. No abstract available.

9

Non-Directed Allylic C-H Acetoxylation in the Presence of Lewis Basic Heterocycles.

Malik HA, Taylor BL, Kerrigan JR, Grob JE, Houk KN, Du Bois J, Hamann LG, Patterson AW. Malik HA, et al. Among authors: patterson aw. Chem Sci. 2014 Jun 1;5(6):2352-2361. doi: 10.1039/C3SC53414F. Chem Sci. 2014. PMID: 25685311 Free PMC article.

10

Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO).

Patnaik A, Axford L, Deng L, Cohick E, Ren X, Loi S, Kecman S, Hollis-Symynkywicz M, Harrison TJ, Papillon JPN, Dales N, Hamann LG, Lee L, Regard JB, Marcinkeviciene J, Marro ML, Patterson AW. Patnaik A, et al. Among authors: patterson aw. Bioorg Med Chem. 2020 Jun 15;28(12):115548. doi: 10.1016/j.bmc.2020.115548. Epub 2020 May 12. Bioorg Med Chem. 2020. PMID: 32503688

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