Drohat AC - Search Results

1

The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase.

Guan X, Madabushi A, Chang DY, Fitzgerald ME, Shi G, Drohat AC, Lu AL. Guan X, et al. Among authors: drohat ac. Nucleic Acids Res. 2007;35(18):6207-18. doi: 10.1093/nar/gkm678. Epub 2007 Sep 12. Nucleic Acids Res. 2007. PMID: 17855402 Free PMC article.

2

Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability.

Bennett MT, Rodgers MT, Hebert AS, Ruslander LE, Eisele L, Drohat AC. Bennett MT, et al. Among authors: drohat ac. J Am Chem Soc. 2006 Sep 27;128(38):12510-9. doi: 10.1021/ja0634829. J Am Chem Soc. 2006. PMID: 16984202 Free PMC article.

3

Excision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG.

Morgan MT, Bennett MT, Drohat AC. Morgan MT, et al. Among authors: drohat ac. J Biol Chem. 2007 Sep 21;282(38):27578-86. doi: 10.1074/jbc.M704253200. Epub 2007 Jun 29. J Biol Chem. 2007. PMID: 17602166 Free PMC article.

4

Structural studies of RNA/DNA polypurine tracts.

Fitzgerald ME, Drohat AC. Fitzgerald ME, et al. Among authors: drohat ac. Chem Biol. 2008 Mar;15(3):203-4. doi: 10.1016/j.chembiol.2008.03.001. Chem Biol. 2008. PMID: 18355716 Free PMC article.

5

Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition.

Maiti A, Morgan MT, Pozharski E, Drohat AC. Maiti A, et al. Among authors: drohat ac. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8890-5. doi: 10.1073/pnas.0711061105. Epub 2008 Jun 27. Proc Natl Acad Sci U S A. 2008. PMID: 18587051 Free PMC article.

6

Coordinating the initial steps of base excision repair. Apurinic/apyrimidinic endonuclease 1 actively stimulates thymine DNA glycosylase by disrupting the product complex.

Fitzgerald ME, Drohat AC. Fitzgerald ME, et al. Among authors: drohat ac. J Biol Chem. 2008 Nov 21;283(47):32680-90. doi: 10.1074/jbc.M805504200. Epub 2008 Sep 19. J Biol Chem. 2008. PMID: 18805789 Free PMC article.

7

Role of two strictly conserved residues in nucleotide flipping and N-glycosylic bond cleavage by human thymine DNA glycosylase.

Maiti A, Morgan MT, Drohat AC. Maiti A, et al. Among authors: drohat ac. J Biol Chem. 2009 Dec 25;284(52):36680-36688. doi: 10.1074/jbc.M109.062356. Epub 2009 Oct 30. J Biol Chem. 2009. PMID: 19880517 Free PMC article.

8

Stoichiometry and affinity for thymine DNA glycosylase binding to specific and nonspecific DNA.

Morgan MT, Maiti A, Fitzgerald ME, Drohat AC. Morgan MT, et al. Among authors: drohat ac. Nucleic Acids Res. 2011 Mar;39(6):2319-29. doi: 10.1093/nar/gkq1164. Epub 2010 Nov 21. Nucleic Acids Res. 2011. PMID: 21097883 Free PMC article.

9

Dependence of substrate binding and catalysis on pH, ionic strength, and temperature for thymine DNA glycosylase: Insights into recognition and processing of G·T mispairs.

Maiti A, Drohat AC. Maiti A, et al. Among authors: drohat ac. DNA Repair (Amst). 2011 May 5;10(5):545-53. doi: 10.1016/j.dnarep.2011.03.004. Epub 2011 Apr 6. DNA Repair (Amst). 2011. PMID: 21474392 Free PMC article.

10

Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites.

Maiti A, Drohat AC. Maiti A, et al. Among authors: drohat ac. J Biol Chem. 2011 Oct 14;286(41):35334-35338. doi: 10.1074/jbc.C111.284620. Epub 2011 Aug 23. J Biol Chem. 2011. PMID: 21862836 Free PMC article.

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