Trepel JB - Search Results

1

Phase I trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignancies.

Kummar S, Gutierrez M, Gardner ER, Donovan E, Hwang K, Chung EJ, Lee MJ, Maynard K, Kalnitskiy M, Chen A, Melillo G, Ryan QC, Conley B, Figg WD, Trepel JB, Zwiebel J, Doroshow JH, Murgo AJ. Kummar S, et al. Among authors: trepel jb. Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5411-7. doi: 10.1158/1078-0432.CCR-07-0791. Clin Cancer Res. 2007. PMID: 17875771 Clinical Trial.

2

Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer.

Thibault A, Samid D, Tompkins AC, Figg WD, Cooper MR, Hohl RJ, Trepel J, Liang B, Patronas N, Venzon DJ, Reed E, Myers CE. Thibault A, et al. Clin Cancer Res. 1996 Mar;2(3):483-91. Clin Cancer Res. 1996. PMID: 9816194 Clinical Trial.

3

Regulation of BRCA1 by protein degradation.

Blagosklonny MV, An WG, Melillo G, Nguyen P, Trepel JB, Neckers LM. Blagosklonny MV, et al. Among authors: trepel jb. Oncogene. 1999 Nov 11;18(47):6460-8. doi: 10.1038/sj.onc.1203068. Oncogene. 1999. PMID: 10597248

4

MS-275, a histone deacetylase inhibitor, selectively induces transforming growth factor beta type II receptor expression in human breast cancer cells.

Lee BI, Park SH, Kim JW, Sausville EA, Kim HT, Nakanishi O, Trepel JB, Kim SJ. Lee BI, et al. Among authors: trepel jb. Cancer Res. 2001 Feb 1;61(3):931-4. Cancer Res. 2001. PMID: 11221885

5

Transcriptional activation of p21(WAF1/CIP1) by apicidin, a novel histone deacetylase inhibitor.

Kim JS, Lee S, Lee T, Lee YW, Trepel JB. Kim JS, et al. Among authors: trepel jb. Biochem Biophys Res Commun. 2001 Mar 9;281(4):866-71. doi: 10.1006/bbrc.2001.4434. Biochem Biophys Res Commun. 2001. PMID: 11237739

6

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy.

Blagosklonny MV, Fojo T, Bhalla KN, Kim JS, Trepel JB, Figg WD, Rivera Y, Neckers LM. Blagosklonny MV, et al. Among authors: trepel jb. Leukemia. 2001 Oct;15(10):1537-43. doi: 10.1038/sj.leu.2402257. Leukemia. 2001. PMID: 11587211

7

Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin.

Chung EJ, Hwang SG, Nguyen P, Lee S, Kim JS, Kim JW, Henkart PA, Bottaro DP, Soon L, Bonvini P, Lee SJ, Karp JE, Oh HJ, Rubin JS, Trepel JB. Chung EJ, et al. Among authors: trepel jb. Blood. 2002 Aug 1;100(3):982-90. doi: 10.1182/blood.v100.3.982. Blood. 2002. PMID: 12130512 Free article.

8

The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells.

Xu W, Yuan X, Jung YJ, Yang Y, Basso A, Rosen N, Chung EJ, Trepel J, Neckers L. Xu W, et al. Cancer Res. 2003 Nov 15;63(22):7777-84. Cancer Res. 2003. PMID: 14633703

9

Enhanced radiation-induced cell killing and prolongation of gammaH2AX foci expression by the histone deacetylase inhibitor MS-275.

Camphausen K, Burgan W, Cerra M, Oswald KA, Trepel JB, Lee MJ, Tofilon PJ. Camphausen K, et al. Among authors: trepel jb. Cancer Res. 2004 Jan 1;64(1):316-21. doi: 10.1158/0008-5472.can-03-2630. Cancer Res. 2004. PMID: 14729640

10

Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells.

Nguyen DM, Schrump WD, Chen GA, Tsai W, Nguyen P, Trepel JB, Schrump DS. Nguyen DM, et al. Among authors: trepel jb. Clin Cancer Res. 2004 Mar 1;10(5):1813-25. doi: 10.1158/1078-0432.ccr-0901-3. Clin Cancer Res. 2004. PMID: 15014036

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