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COMET and the challenge of drug safety screening.
Nicholson J, Keun H, Ebbels T. Nicholson J, et al. Among authors: ebbels t. J Proteome Res. 2007 Nov;6(11):4098-9. doi: 10.1021/pr078006b. Epub 2007 Sep 25. J Proteome Res. 2007. PMID: 17892277 No abstract available.
Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project.
Lindon JC, Nicholson JK, Holmes E, Antti H, Bollard ME, Keun H, Beckonert O, Ebbels TM, Reily MD, Robertson D, Stevens GJ, Luke P, Breau AP, Cantor GH, Bible RH, Niederhauser U, Senn H, Schlotterbeck G, Sidelmann UG, Laursen SM, Tymiak A, Car BD, Lehman-McKeeman L, Colet JM, Loukaci A, Thomas C. Lindon JC, et al. Toxicol Appl Pharmacol. 2003 Mar 15;187(3):137-46. doi: 10.1016/s0041-008x(02)00079-0. Toxicol Appl Pharmacol. 2003. PMID: 12662897
A combination of transcriptomics and metabolomics uncovers enhanced bile acid biosynthesis in HepG2 cells expressing CCAAT/enhancer-binding protein β (C/EBPβ), hepatocyte nuclear factor 4α (HNF4α), and constitutive androstane receptor (CAR).
Blazquez M, Carretero A, Ellis JK, Athersuch TJ, Cavill R, Ebbels TM, Keun HC, Castell JV, Lahoz A, Bort R. Blazquez M, et al. J Proteome Res. 2013 Jun 7;12(6):2732-41. doi: 10.1021/pr400085n. Epub 2013 May 15. J Proteome Res. 2013. PMID: 23641669
Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP study.
Yap IK, Brown IJ, Chan Q, Wijeyesekera A, Garcia-Perez I, Bictash M, Loo RL, Chadeau-Hyam M, Ebbels T, De Iorio M, Maibaum E, Zhao L, Kesteloot H, Daviglus ML, Stamler J, Nicholson JK, Elliott P, Holmes E. Yap IK, et al. Among authors: ebbels t. J Proteome Res. 2010 Dec 3;9(12):6647-54. doi: 10.1021/pr100798r. Epub 2010 Nov 2. J Proteome Res. 2010. PMID: 20853909 Free PMC article.
120 results