Kohlbrenner WE - Search Results

1

Activity of a potent hepatitis C virus polymerase inhibitor in the chimpanzee model.

Chen CM, He Y, Lu L, Lim HB, Tripathi RL, Middleton T, Hernandez LE, Beno DW, Long MA, Kati WM, Bosse TD, Larson DP, Wagner R, Lanford RE, Kohlbrenner WE, Kempf DJ, Pilot-Matias TJ, Molla A. Chen CM, et al. Among authors: kohlbrenner we. Antimicrob Agents Chemother. 2007 Dec;51(12):4290-6. doi: 10.1128/AAC.00723-07. Epub 2007 Oct 1. Antimicrob Agents Chemother. 2007. PMID: 17908950 Free PMC article.

2

Synthesis of potent pyrrolidine influenza neuraminidase inhibitors.

Krueger AC, Xu Y, Kati WM, Kempf DJ, Maring CJ, McDaniel KF, Molla A, Montgomery D, Kohlbrenner WE. Krueger AC, et al. Among authors: kohlbrenner we. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1692-5. doi: 10.1016/j.bmcl.2008.01.048. Epub 2008 Jan 18. Bioorg Med Chem Lett. 2008. PMID: 18242993

3

Hepatitis C NS5B polymerase inhibitors: 4,4-Dialkyl-1-hydroxy-3-oxo-3,4-dihydronaphthalene-3-yl benzothiadiazine derivatives.

Hutchinson DK, Rosenberg T, Klein LL, Bosse TD, Larson DP, He W, Jiang WW, Kati WM, Kohlbrenner WE, Liu Y, Masse SV, Middleton T, Molla A, Montgomery DA, Beno DW, Stewart KD, Stoll VS, Kempf DJ. Hutchinson DK, et al. Among authors: kohlbrenner we. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3887-90. doi: 10.1016/j.bmcl.2008.06.043. Epub 2008 Jun 18. Bioorg Med Chem Lett. 2008. PMID: 18599294

4

In vitro characterization of A-315675, a highly potent inhibitor of A and B strain influenza virus neuraminidases and influenza virus replication.

Kati WM, Montgomery D, Carrick R, Gubareva L, Maring C, McDaniel K, Steffy K, Molla A, Hayden F, Kempf D, Kohlbrenner W. Kati WM, et al. Antimicrob Agents Chemother. 2002 Apr;46(4):1014-21. doi: 10.1128/AAC.46.4.1014-1021.2002. Antimicrob Agents Chemother. 2002. PMID: 11897583 Free PMC article.

5

Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines.

Pratt JK, Donner P, McDaniel KF, Maring CJ, Kati WM, Mo H, Middleton T, Liu Y, Ng T, Xie Q, Zhang R, Montgomery D, Molla A, Kempf DJ, Kohlbrenner W. Pratt JK, et al. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1577-82. doi: 10.1016/j.bmcl.2005.01.071. Bioorg Med Chem Lett. 2005. PMID: 15745800

6

Inhibitors of hepatitis C virus polymerase: synthesis and biological characterization of unsymmetrical dialkyl-hydroxynaphthalenoyl-benzothiadiazines.

Wagner R, Larson DP, Beno DW, Bosse TD, Darbyshire JF, Gao Y, Gates BD, He W, Henry RF, Hernandez LE, Hutchinson DK, Jiang WW, Kati WM, Klein LL, Koev G, Kohlbrenner W, Krueger AC, Liu J, Liu Y, Long MA, Maring CJ, Masse SV, Middleton T, Montgomery DA, Pratt JK, Stuart P, Molla A, Kempf DJ. Wagner R, et al. J Med Chem. 2009 Mar 26;52(6):1659-69. doi: 10.1021/jm8010965. J Med Chem. 2009. PMID: 19226162

7

Selection and characterization of varicella-zoster virus variants resistant to (R)-9-[4-hydroxy-2-(hydroxymethy)butyl]guanine.

Ng TI, Shi Y, Huffaker HJ, Kati W, Liu Y, Chen CM, Lin Z, Maring C, Kohlbrenner WE, Molla A. Ng TI, et al. Among authors: kohlbrenner we. Antimicrob Agents Chemother. 2001 Jun;45(6):1629-36. doi: 10.1128/AAC.45.6.1629-1636.2001. Antimicrob Agents Chemother. 2001. PMID: 11353604 Free PMC article.

8

Inhibition of human immunodeficiency virus type I integrase by naphthamidines and 2-aminobenzimidazoles.

Middleton T, Lim HB, Montgomery D, Rockway T, Tang H, Cheng X, Lu L, Mo H, Kohlbrenner WE, Molla A, Kati WM. Middleton T, et al. Among authors: kohlbrenner we. Antiviral Res. 2004 Oct;64(1):35-45. doi: 10.1016/j.antiviral.2004.04.007. Antiviral Res. 2004. PMID: 15451177

9

In vitro selection and characterization of influenza A (A/N9) virus variants resistant to a novel neuraminidase inhibitor, A-315675.

Molla A, Kati W, Carrick R, Steffy K, Shi Y, Montgomery D, Gusick N, Stoll VS, Stewart KD, Ng TI, Maring C, Kempf DJ, Kohlbrenner W. Molla A, et al. J Virol. 2002 Jun;76(11):5380-6. doi: 10.1128/jvi.76.11.5380-5386.2002. J Virol. 2002. PMID: 11991966 Free PMC article.

10

Investigating the origin of the slow-binding inhibition of HCV NS3 serine protease by a novel substrate based inhibitor.

Liu Y, Saldivar A, Bess J, Solomon L, Chen CM, Tripathi R, Barrett L, Richardson PL, Molla A, Kohlbrenner W, Kati W. Liu Y, et al. Biochemistry. 2003 Jul 29;42(29):8862-9. doi: 10.1021/bi034661v. Biochemistry. 2003. PMID: 12873147

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