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Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.
Lustgarten MS, Jang YC, Liu Y, Muller FL, Qi W, Steinhelper M, Brooks SV, Larkin L, Shimizu T, Shirasawa T, McManus LM, Bhattacharya A, Richardson A, Van Remmen H. Lustgarten MS, et al. Among authors: muller fl. Am J Physiol Cell Physiol. 2009 Dec;297(6):C1520-32. doi: 10.1152/ajpcell.00372.2009. Epub 2009 Sep 23. Am J Physiol Cell Physiol. 2009. PMID: 19776389 Free PMC article.
Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels.
Lustgarten MS, Bhattacharya A, Muller FL, Jang YC, Shimizu T, Shirasawa T, Richardson A, Van Remmen H. Lustgarten MS, et al. Among authors: muller fl. Biochem Biophys Res Commun. 2012 Jun 8;422(3):515-21. doi: 10.1016/j.bbrc.2012.05.055. Epub 2012 May 18. Biochem Biophys Res Commun. 2012. PMID: 22613204 Free PMC article.
Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance.
Abdul-Ghani MA, Muller FL, Liu Y, Chavez AO, Balas B, Zuo P, Chang Z, Tripathy D, Jani R, Molina-Carrion M, Monroy A, Folli F, Van Remmen H, DeFronzo RA. Abdul-Ghani MA, et al. Among authors: muller fl. Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E678-85. doi: 10.1152/ajpendo.90287.2008. Epub 2008 Jul 1. Am J Physiol Endocrinol Metab. 2008. PMID: 18593850 Free article.
MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging.
Lustgarten MS, Jang YC, Liu Y, Qi W, Qin Y, Dahia PL, Shi Y, Bhattacharya A, Muller FL, Shimizu T, Shirasawa T, Richardson A, Van Remmen H. Lustgarten MS, et al. Among authors: muller fl. Aging Cell. 2011 Jun;10(3):493-505. doi: 10.1111/j.1474-9726.2011.00695.x. Epub 2011 Apr 5. Aging Cell. 2011. PMID: 21385310 Free PMC article.
79 results