Uchil V - Search Results

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A novel strategy to assemble the beta-diketo acid pharmacophore of HIV integrase inhibitors on purine nucleobase scaffolds.

Uchil V, Seo B, Nair V. Uchil V, et al. J Org Chem. 2007 Oct 26;72(22):8577-9. doi: 10.1021/jo701336r. Epub 2007 Oct 5. J Org Chem. 2007. PMID: 17918897 Free PMC article.

Beta-diketo acids with purine nucleobase scaffolds: novel, selective inhibitors of the strand transfer step of HIV integrase.

Nair V, Uchil V, Neamati N. Nair V, et al. Among authors: uchil v. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1920-3. doi: 10.1016/j.bmcl.2005.12.093. Epub 2006 Jan 24. Bioorg Med Chem Lett. 2006. PMID: 16439124

Biologically-validated HIV integrase inhibitors with nucleobase scaffolds: structure, synthesis, chemical biology, molecular modeling, and antiviral activity.

Nair V, Uchil V, Chi G, Dams I, Cox A, Seo B. Nair V, et al. Among authors: uchil v. Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):665-8. doi: 10.1080/15257770701490563. Nucleosides Nucleotides Nucleic Acids. 2007. PMID: 18066876

Discovery of a Potent HIV Integrase Inhibitor that Leads to a Prodrug with Significant anti-HIV Activity.

Seo BI, Uchil VR, Okello M, Mishra S, Ma XH, Nishonov M, Shu Q, Chi G, Nair V. Seo BI, et al. Among authors: uchil vr. ACS Med Chem Lett. 2011 Oct 5;2(12):877-881. doi: 10.1021/ml2001246. ACS Med Chem Lett. 2011. PMID: 22328963 Free PMC article.

Ribonucleosides bearing Michael acceptors: synthesis, molecular docking, enzyme inhibition data and antiviral activity.

Nair V, Uchil V, Ma X, Zhu Q, Zhang F, Bonsu E. Nair V, et al. Among authors: uchil v. Nucleic Acids Symp Ser (Oxf). 2008;(52):625-6. doi: 10.1093/nass/nrn316. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776535 No abstract available.

IMPDH as a biological probe for RNA antiviral drug discovery: synthesis, enzymology, molecular docking, and antiviral activity of new ribonucleosides with surrogate bases.

Nair V, Ma X, Shu Q, Zhang F, Uchil V, Cherukupalli GR. Nair V, et al. Among authors: uchil v. Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):651-4. doi: 10.1080/15257770701490506. Nucleosides Nucleotides Nucleic Acids. 2007. PMID: 18066873

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