Neubig RR - Search Results

1

Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of G protein signaling-insensitive G184S Gnai2 allele.

Huang X, Charbeneau RA, Fu Y, Kaur K, Gerin I, MacDougald OA, Neubig RR. Huang X, et al. Among authors: neubig rr. Diabetes. 2008 Jan;57(1):77-85. doi: 10.2337/db07-0599. Epub 2007 Oct 10. Diabetes. 2008. PMID: 17928396

2

Regulator of G protein signaling proteins: novel multifunctional drug targets.

Zhong H, Neubig RR. Zhong H, et al. Among authors: neubig rr. J Pharmacol Exp Ther. 2001 Jun;297(3):837-45. J Pharmacol Exp Ther. 2001. PMID: 11356902 Review.

3

RGS-insensitive G-protein mutations to study the role of endogenous RGS proteins.

Fu Y, Zhong H, Nanamori M, Mortensen RM, Huang X, Lan K, Neubig RR. Fu Y, et al. Among authors: neubig rr. Methods Enzymol. 2004;389:229-43. doi: 10.1016/S0076-6879(04)89014-1. Methods Enzymol. 2004. PMID: 15313569 Review.

4

Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects.

Fu Y, Huang X, Zhong H, Mortensen RM, D'Alecy LG, Neubig RR. Fu Y, et al. Among authors: neubig rr. Circ Res. 2006 Mar 17;98(5):659-66. doi: 10.1161/01.RES.0000207497.50477.60. Epub 2006 Feb 2. Circ Res. 2006. PMID: 16456099

5

Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele.

Huang X, Fu Y, Charbeneau RA, Saunders TL, Taylor DK, Hankenson KD, Russell MW, D'Alecy LG, Neubig RR. Huang X, et al. Among authors: neubig rr. Mol Cell Biol. 2006 Sep;26(18):6870-9. doi: 10.1128/MCB.00314-06. Mol Cell Biol. 2006. PMID: 16943428 Free PMC article.

6

Endogenous RGS proteins modulate SA and AV nodal functions in isolated heart: implications for sick sinus syndrome and AV block.

Fu Y, Huang X, Piao L, Lopatin AN, Neubig RR. Fu Y, et al. Among authors: neubig rr. Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2532-9. doi: 10.1152/ajpheart.01391.2006. Epub 2007 Feb 2. Am J Physiol Heart Circ Physiol. 2007. PMID: 17277016 Free article.

Using knock-in mice in which Galpha(i2)-RGS binding and negative regulation are disrupted by a genomic Galpha(i2)G184S (GS) point mutation, we recently (Fu Y, Huang X, Zhong H, Mortensen RM, D'Alecy LG, Neubig RR. Circ Res 98: 659-666, 2006) showed that endogenous R …

Using knock-in mice in which Galpha(i2)-RGS binding and negative regulation are disrupted by a genomic Galpha(i2)G184S (GS) point mutation, …

7

Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity.

Goldenstein BL, Nelson BW, Xu K, Luger EJ, Pribula JA, Wald JM, O'Shea LA, Weinshenker D, Charbeneau RA, Huang X, Neubig RR, Doze VA. Goldenstein BL, et al. Among authors: neubig rr. Mol Pharmacol. 2009 May;75(5):1222-30. doi: 10.1124/mol.108.054296. Epub 2009 Feb 18. Mol Pharmacol. 2009. PMID: 19225179 Free PMC article.

8

GNAI2 and regulators of G protein signaling as a potential Noonan syndrome mechanism.

Huang X, Fu Y, Charbeneau RA, Neubig RR. Huang X, et al. Among authors: neubig rr. Med Hypotheses. 2009 Jul;73(1):56-9. doi: 10.1016/j.mehy.2009.01.040. Epub 2009 Mar 17. Med Hypotheses. 2009. PMID: 19282110 Free PMC article.

9

Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins.

Icaza EE, Huang X, Fu Y, Neubig RR, Baghdoyan HA, Lydic R. Icaza EE, et al. Among authors: neubig rr. Anesth Analg. 2009 Nov;109(5):1500-5. doi: 10.1213/ANE.0b013e3181ba7815. Anesth Analg. 2009. PMID: 19843788 Free PMC article.

10

RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects.

Talbot JN, Jutkiewicz EM, Graves SM, Clemans CF, Nicol MR, Mortensen RM, Huang X, Neubig RR, Traynor JR. Talbot JN, et al. Among authors: neubig rr. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11086-91. doi: 10.1073/pnas.1000003107. Epub 2010 Jun 2. Proc Natl Acad Sci U S A. 2010. PMID: 20534514 Free PMC article.

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