Li WM - Search Results

1

The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine.

Yu H, Li WM, Kan KK, Ho JM, Carlier PR, Pang YP, Gu ZM, Zhong Z, Chan K, Wang YT, Han YF. Yu H, et al. Among authors: li wm. J Pharm Biomed Anal. 2008 Jan 7;46(1):75-81. doi: 10.1016/j.jpba.2007.08.027. Epub 2007 Sep 4. J Pharm Biomed Anal. 2008. PMID: 17931815

2

Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer's dimer bis(7)-tacrine.

Zhang L, Yu H, Li WM, Cheung MC, Pang YP, Gu ZM, Chan K, Wang YT, Zuo Z, Han YF. Zhang L, et al. Among authors: li wm. Int J Pharm. 2008 Jun 5;357(1-2):85-94. doi: 10.1016/j.ijpharm.2008.01.037. Epub 2008 Feb 2. Int J Pharm. 2008. PMID: 18358649

3

Development and validation of an HPLC-DAD method for bis(12)-hupyridone and its application to a pharmacokinetic study.

Yu H, Li WM, Cheung MC, Zuo Z, Carlier PR, Gu ZM, Chan K, Huang M, Wang YT, Han YF. Yu H, et al. Among authors: li wm. J Pharm Biomed Anal. 2009 Feb 20;49(2):410-4. doi: 10.1016/j.jpba.2008.11.013. Epub 2008 Nov 24. J Pharm Biomed Anal. 2009. PMID: 19124214

4

Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood.

Yu H, Ho JM, Kan KK, Cheng BW, Li WM, Zhang L, Lin G, Pang YP, Gu ZM, Chan K, Wang YT, Han YF. Yu H, et al. Among authors: li wm. J Pharm Biomed Anal. 2007 Sep 3;44(5):1133-8. doi: 10.1016/j.jpba.2007.05.028. Epub 2007 May 25. J Pharm Biomed Anal. 2007. PMID: 17628383

5

Selective and sensitive determination of bis(7)-tacrine, a high erythrocyte binding acetylcholinesterase inhibitor, in rat plasma by high-performance liquid chromatography-tandem mass spectrometry.

Zhang L, Yu H, Li WM, Cheung MC, Pang YP, Lin G, Wang YT, Zuo Z, Han YF. Zhang L, et al. Among authors: li wm. Biomed Chromatogr. 2008 Apr;22(4):414-20. doi: 10.1002/bmc.949. Biomed Chromatogr. 2008. PMID: 18059054

6

East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.

Li WM, Kan KK, Carlier PR, Pang YP, Han YF. Li WM, et al. Curr Alzheimer Res. 2007 Sep;4(4):386-96. doi: 10.2174/156720507781788918. Curr Alzheimer Res. 2007. PMID: 17908041 Review.

7

Neuroprotection via inhibition of nitric oxide synthase by bis(7)-tacrine.

Li W, Lee NT, Fu H, Kan KK, Pang Y, Li M, Tsim KW, Li X, Han Y. Li W, et al. Neuroreport. 2006 Apr 3;17(5):471-4. doi: 10.1097/01.wnr.0000209014.09094.72. Neuroreport. 2006. PMID: 16543809

8

Bis(7)-tacrine, a promising anti-Alzheimer's dimer, affords dose- and time-dependent neuroprotection against transient focal cerebral ischemia.

Zhao Y, Li W, Chow PC, Lau DT, Lee NT, Pang Y, Zhang X, Wang X, Han Y. Zhao Y, et al. Neurosci Lett. 2008 Jul 11;439(2):160-4. doi: 10.1016/j.neulet.2008.05.007. Epub 2008 May 8. Neurosci Lett. 2008. PMID: 18515007

9

Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets.

Li W, Mak M, Jiang H, Wang Q, Pang Y, Chen K, Han Y. Li W, et al. Neurotherapeutics. 2009 Jan;6(1):187-201. doi: 10.1016/j.nurt.2008.10.040. Neurotherapeutics. 2009. PMID: 19110209 Free PMC article. Review.

10

Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors.

Liu YW, Li CY, Luo JL, Li WM, Fu HJ, Lao YZ, Liu LJ, Pang YP, Chang DC, Li ZW, Peoples RW, Ai YX, Han YF. Liu YW, et al. Among authors: li zw, li cy, li wm. Biochem Biophys Res Commun. 2008 May 16;369(4):1007-11. doi: 10.1016/j.bbrc.2008.02.133. Epub 2008 Mar 6. Biochem Biophys Res Commun. 2008. PMID: 18328812

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