Broyde S - Search Results

1

Dynamics of a benzo[a]pyrene-derived guanine DNA lesion in TGT and CGC sequence contexts: enhanced mobility in TGT explains conformational heterogeneity, flexible bending, and greater susceptibility to nucleotide excision repair.

Cai Y, Patel DJ, Geacintov NE, Broyde S. Cai Y, et al. Among authors: broyde s. J Mol Biol. 2007 Nov 23;374(2):292-305. doi: 10.1016/j.jmb.2007.09.034. Epub 2007 Sep 19. J Mol Biol. 2007. PMID: 17942115 Free PMC article.

2

Solution conformation of the major adduct between the carcinogen (+)-anti-benzo[a]pyrene diol epoxide and DNA.

Cosman M, de los Santos C, Fiala R, Hingerty BE, Singh SB, Ibanez V, Margulis LA, Live D, Geacintov NE, Broyde S, et al. Cosman M, et al. Among authors: broyde s. Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1914-8. doi: 10.1073/pnas.89.5.1914. Proc Natl Acad Sci U S A. 1992. PMID: 1311854 Free PMC article.

3

Influence of benzo[a]pyrene diol epoxide chirality on solution conformations of DNA covalent adducts: the (-)-trans-anti-[BP]G.C adduct structure and comparison with the (+)-trans-anti-[BP]G.C enantiomer.

de los Santos C, Cosman M, Hingerty BE, Ibanez V, Margulis LA, Geacintov NE, Broyde S, Patel DJ. de los Santos C, et al. Among authors: broyde s. Biochemistry. 1992 Jun 16;31(23):5245-52. doi: 10.1021/bi00138a002. Biochemistry. 1992. PMID: 1606148

4

Structures of the (+)- and (-)-trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyre ne adducts to guanine-N2 in a duplex dodecamer.

Singh SB, Hingerty BE, Singh UC, Greenberg JP, Geacintov NE, Broyde S. Singh SB, et al. Among authors: broyde s. Cancer Res. 1991 Jul 1;51(13):3482-92. Cancer Res. 1991. PMID: 1905197

5

NMR and computational characterization of mitomycin cross-linked to adjacent deoxyguanosines in the minor groove of the d(T-A-C-G-T-A).d(T-A-C-G-T-A) duplex.

Norman D, Live D, Sastry M, Lipman R, Hingerty BE, Tomasz M, Broyde S, Patel DJ. Norman D, et al. Among authors: broyde s. Biochemistry. 1990 Mar 20;29(11):2861-75. doi: 10.1021/bi00463a032. Biochemistry. 1990. PMID: 2346750

6

NMR and computational characterization of the N-(deoxyguanosin-8-yl)aminofluorene adduct [(AF)G] opposite adenosine in DNA: (AF)G[syn].A[anti] pair formation and its pH dependence.

Norman D, Abuaf P, Hingerty BE, Live D, Grunberger D, Broyde S, Patel DJ. Norman D, et al. Among authors: broyde s. Biochemistry. 1989 Sep 5;28(18):7462-76. doi: 10.1021/bi00444a046. Biochemistry. 1989. PMID: 2819081

7

Structural alignments of (+)- and (-)-trans-anti-benzo[a]pyrene-dG adducts positioned at a DNA template-primer junction.

Cosman M, Hingerty BE, Geacintov NE, Broyde S, Patel DJ. Cosman M, et al. Among authors: broyde s. Biochemistry. 1995 Nov 21;34(46):15334-50. doi: 10.1021/bi00046a043. Biochemistry. 1995. PMID: 7578150

8

Solution conformation of [AF]dG opposite a -1 deletion site in a DNA duplex: intercalation of the covalently attached aminofluorene ring into the helix with base displacement of the C8-modified Syn guanine into the major groove.

Mao B, Cosman M, Hingerty BE, Broyde S, Patel DJ. Mao B, et al. Among authors: broyde s. Biochemistry. 1995 May 9;34(18):6226-38. doi: 10.1021/bi00018a027. Biochemistry. 1995. PMID: 7742328

9

Solution conformation of the (-)-trans-anti-5-methylchrysene-dG adduct opposite dC in a DNA duplex: DNA bending associated with wedging of the methyl group of 5-methylchrysene to the 3'-side of the modification site.

Cosman M, Xu R, Hingerty BE, Amin S, Harvey RG, Geacintov NE, Broyde S, Patel DJ. Cosman M, et al. Among authors: broyde s. Biochemistry. 1995 May 9;34(18):6247-60. doi: 10.1021/bi00018a029. Biochemistry. 1995. PMID: 7742330

10

Solution conformation of the (-)-trans-anti-benzo[c]phenanthrene-dA ([BPh]dA) adduct opposite dT in a DNA duplex: intercalation of the covalently attached benzo[c]phenanthrenyl ring to the 3'-side of the adduct site and comparison with the (+)-trans-anti-[BPh]dA opposite dT stereoisomer.

Cosman M, Laryea A, Fiala R, Hingerty BE, Amin S, Geacintov NE, Broyde S, Patel DJ. Cosman M, et al. Among authors: broyde s. Biochemistry. 1995 Jan 31;34(4):1295-307. doi: 10.1021/bi00004a024. Biochemistry. 1995. PMID: 7827077

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