Geacintov NE - Search Results

1

Dynamics of a benzo[a]pyrene-derived guanine DNA lesion in TGT and CGC sequence contexts: enhanced mobility in TGT explains conformational heterogeneity, flexible bending, and greater susceptibility to nucleotide excision repair.

Cai Y, Patel DJ, Geacintov NE, Broyde S. Cai Y, et al. Among authors: geacintov ne. J Mol Biol. 2007 Nov 23;374(2):292-305. doi: 10.1016/j.jmb.2007.09.034. Epub 2007 Sep 19. J Mol Biol. 2007. PMID: 17942115 Free PMC article.

2

DNA adducts from a tumorigenic metabolite of benzo[a]pyrene block human RNA polymerase II elongation in a sequence- and stereochemistry-dependent manner.

Perlow RA, Kolbanovskii A, Hingerty BE, Geacintov NE, Broyde S, Scicchitano DA. Perlow RA, et al. Among authors: geacintov ne. J Mol Biol. 2002 Aug 2;321(1):29-47. doi: 10.1016/s0022-2836(02)00593-4. J Mol Biol. 2002. PMID: 12139931

3

Relating repair susceptibility of carcinogen-damaged DNA with structural distortion and thermodynamic stability.

Wu M, Yan S, Patel DJ, Geacintov NE, Broyde S. Wu M, et al. Among authors: geacintov ne. Nucleic Acids Res. 2002 Aug 1;30(15):3422-32. doi: 10.1093/nar/gkf427. Nucleic Acids Res. 2002. PMID: 12140327 Free PMC article.

4

Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery.

Geacintov NE, Broyde S, Buterin T, Naegeli H, Wu M, Yan S, Patel DJ. Geacintov NE, et al. Biopolymers. 2002 Nov 5;65(3):202-10. doi: 10.1002/bip.10239. Biopolymers. 2002. PMID: 12228925 Review.

5

Role of base sequence context in conformational equilibria and nucleotide excision repair of benzo[a]pyrene diol epoxide-adenine adducts.

Yan S, Wu M, Buterin T, Naegeli H, Geacintov NE, Broyde S. Yan S, et al. Among authors: geacintov ne. Biochemistry. 2003 Mar 4;42(8):2339-54. doi: 10.1021/bi0270081. Biochemistry. 2003. PMID: 12600201

6

Human RNA polymerase II is partially blocked by DNA adducts derived from tumorigenic benzo[c]phenanthrene diol epoxides: relating biological consequences to conformational preferences.

Schinecker TM, Perlow RA, Broyde S, Geacintov NE, Scicchitano DA. Schinecker TM, et al. Among authors: geacintov ne. Nucleic Acids Res. 2003 Oct 15;31(20):6004-15. doi: 10.1093/nar/gkg771. Nucleic Acids Res. 2003. PMID: 14530448 Free PMC article.

7

Conformational searches elucidate effects of stereochemistry on structures of deoxyadenosine covalently bound to tumorigenic metabolites of benzo[C] phenanthrene.

Wu M, Yan SF, Tan J, Patel DJ, Geacintov NE, Broyde S. Wu M, et al. Among authors: geacintov ne. Front Biosci. 2004 Sep 1;9:2807-18. doi: 10.2741/1438. Front Biosci. 2004. PMID: 15353316 Free PMC article.

8

Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement.

Zhang N, Lin C, Huang X, Kolbanovskiy A, Hingerty BE, Amin S, Broyde S, Geacintov NE, Patel DJ. Zhang N, et al. Among authors: geacintov ne. J Mol Biol. 2005 Mar 4;346(4):951-65. doi: 10.1016/j.jmb.2004.12.027. Epub 2004 Dec 31. J Mol Biol. 2005. PMID: 15701509 Free PMC article.

9

Accommodation of a 1S-(-)-benzo[c]phenanthrenyl-N6-dA adduct in the Y-family Dpo4 DNA polymerase active site: structural insights through molecular dynamics simulations.

Wang L, Wu M, Yan SF, Patel DJ, Geacintov NE, Broyde S. Wang L, et al. Among authors: geacintov ne. Chem Res Toxicol. 2005 Mar;18(3):441-56. doi: 10.1021/tx049786v. Chem Res Toxicol. 2005. PMID: 15777084 Free PMC article.

10

Exocyclic amino groups of flanking guanines govern sequence-dependent adduct conformations and local structural distortions for minor groove-aligned benzo[a]pyrenyl-guanine lesions in a GG mutation hotspot context.

Rodríguez FA, Cai Y, Lin C, Tang Y, Kolbanovskiy A, Amin S, Patel DJ, Broyde S, Geacintov NE. Rodríguez FA, et al. Among authors: geacintov ne. Nucleic Acids Res. 2007;35(5):1555-68. doi: 10.1093/nar/gkm022. Epub 2007 Feb 7. Nucleic Acids Res. 2007. PMID: 17287290 Free PMC article.

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