Cai SX - Search Results

1

Discovery and structure-activity relationship of N-phenyl-1H-pyrazolo[3,4-b]quinolin-4-amines as a new series of potent apoptosis inducers.

Zhang HZ, Claassen G, Crogran-Grundy C, Tseng B, Drewe J, Cai SX. Zhang HZ, et al. Among authors: cai sx. Bioorg Med Chem. 2008 Jan 1;16(1):222-31. doi: 10.1016/j.bmc.2007.09.046. Epub 2007 Oct 4. Bioorg Med Chem. 2008. PMID: 17950608

2

Discovery of substituted N-phenyl nicotinamides as potent inducers of apoptosis using a cell- and caspase-based high throughput screening assay.

Cai SX, Nguyen B, Jia S, Herich J, Guastella J, Reddy S, Tseng B, Drewe J, Kasibhatla S. Cai SX, et al. J Med Chem. 2003 Jun 5;46(12):2474-81. doi: 10.1021/jm0205200. J Med Chem. 2003. PMID: 12773051

3

Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay.

Zhang HZ, Kasibhatla S, Wang Y, Herich J, Guastella J, Tseng B, Drewe J, Cai SX. Zhang HZ, et al. Among authors: cai sx. Bioorg Med Chem. 2004 Jan 15;12(2):309-17. doi: 10.1016/j.bmc.2003.11.013. Bioorg Med Chem. 2004. PMID: 14723951

4

Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid.

Wang Y, Huang JC, Zhou ZL, Yang W, Guastella J, Drewe J, Cai SX. Wang Y, et al. Among authors: cai sx. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1269-72. doi: 10.1016/j.bmcl.2003.12.065. Bioorg Med Chem Lett. 2004. PMID: 14980679

5

Discovery and SAR of indole-2-carboxylic acid benzylidene-hydrazides as a new series of potent apoptosis inducers using a cell-based HTS assay.

Zhang HZ, Drewe J, Tseng B, Kasibhatla S, Cai SX. Zhang HZ, et al. Among authors: cai sx. Bioorg Med Chem. 2004 Jul 1;12(13):3649-55. doi: 10.1016/j.bmc.2004.04.017. Bioorg Med Chem. 2004. PMID: 15186849

6

Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: SAR of the N-protecting group.

Cai SX, Guan L, Jia S, Wang Y, Yang W, Tseng B, Drewe J. Cai SX, et al. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5295-300. doi: 10.1016/j.bmcl.2004.08.027. Bioorg Med Chem Lett. 2004. PMID: 15454214

7

Discovery and mechanism of action of a novel series of apoptosis inducers with potential vascular targeting activity.

Kasibhatla S, Gourdeau H, Meerovitch K, Drewe J, Reddy S, Qiu L, Zhang H, Bergeron F, Bouffard D, Yang Q, Herich J, Lamothe S, Cai SX, Tseng B. Kasibhatla S, et al. Among authors: cai sx. Mol Cancer Ther. 2004 Nov;3(11):1365-74. Mol Cancer Ther. 2004. PMID: 15542775

8

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group.

Kemnitzer W, Drewe J, Jiang S, Zhang H, Wang Y, Zhao J, Jia S, Herich J, Labreque D, Storer R, Meerovitch K, Bouffard D, Rej R, Denis R, Blais C, Lamothe S, Attardo G, Gourdeau H, Tseng B, Kasibhatla S, Cai SX. Kemnitzer W, et al. Among authors: cai sx. J Med Chem. 2004 Dec 2;47(25):6299-310. doi: 10.1021/jm049640t. J Med Chem. 2004. PMID: 15566300

9

Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 alpha-amino acid by a alpha-hydroxy acid.

Wang Y, Guan L, Jia S, Tseng B, Drewe J, Cai SX. Wang Y, et al. Among authors: cai sx. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1379-83. doi: 10.1016/j.bmcl.2005.01.007. Bioorg Med Chem Lett. 2005. PMID: 15713391

10

The discovery and mechanism of action of novel tumor-selective and apoptosis-inducing 3,5-diaryl-1,2,4-oxadiazole series using a chemical genetics approach.

Jessen KA, English NM, Yu Wang J, Maliartchouk S, Archer SP, Qiu L, Brand R, Kuemmerle J, Zhang HZ, Gehlsen K, Drewe J, Tseng B, Cai SX, Kasibhatla S. Jessen KA, et al. Among authors: cai sx. Mol Cancer Ther. 2005 May;4(5):761-71. doi: 10.1158/1535-7163.MCT-04-0333. Mol Cancer Ther. 2005. PMID: 15897240

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