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Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120.
Curreli F, Belov DS, Kwon YD, Ramesh R, Furimsky AM, O'Loughlin K, Byrge PC, Iyer LV, Mirsalis JC, Kurkin AV, Altieri A, Debnath AK. Curreli F, et al. Among authors: iyer lv. Eur J Med Chem. 2018 Jun 25;154:367-391. doi: 10.1016/j.ejmech.2018.04.062. Epub 2018 May 12. Eur J Med Chem. 2018. PMID: 29860061 Free PMC article.
A systematic screen of FDA-approved drugs for inhibitors of biological threat agents.
Madrid PB, Chopra S, Manger ID, Gilfillan L, Keepers TR, Shurtleff AC, Green CE, Iyer LV, Dilks HH, Davey RA, Kolokoltsov AA, Carrion R Jr, Patterson JL, Bavari S, Panchal RG, Warren TK, Wells JB, Moos WH, Burke RL, Tanga MJ. Madrid PB, et al. Among authors: iyer lv. PLoS One. 2013;8(4):e60579. doi: 10.1371/journal.pone.0060579. Epub 2013 Apr 5. PLoS One. 2013. PMID: 23577127 Free PMC article.
Pharmacokinetics and metabolism of (R,R)-methoxyfenoterol in rat.
Siluk D, Mager DE, Kim HS, Wang Y, Furimsky AM, Ta A, Iyer LV, Green CE, Wainer IW. Siluk D, et al. Among authors: iyer lv. Xenobiotica. 2010 Mar;40(3):195-206. doi: 10.3109/00498250903434533. Xenobiotica. 2010. PMID: 20039779 Free PMC article.
44 results