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Page 1
Fat depot-related differences in gene expression, adiponectin secretion, and insulin action and signalling in human adipocytes differentiated in vitro from precursor stromal cells.
Perrini S, Laviola L, Cignarelli A, Melchiorre M, De Stefano F, Caccioppoli C, Natalicchio A, Orlando MR, Garruti G, De Fazio M, Catalano G, Memeo V, Giorgino R, Giorgino F. Perrini S, et al. Among authors: orlando mr. Diabetologia. 2008 Jan;51(1):155-64. doi: 10.1007/s00125-007-0841-7. Epub 2007 Oct 25. Diabetologia. 2008. PMID: 17960360
Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway.
Natalicchio A, Labarbuta R, Tortosa F, Biondi G, Marrano N, Peschechera A, Carchia E, Orlando MR, Leonardini A, Cignarelli A, Marchetti P, Perrini S, Laviola L, Giorgino F. Natalicchio A, et al. Among authors: orlando mr. Diabetologia. 2013 Nov;56(11):2456-66. doi: 10.1007/s00125-013-3028-4. Epub 2013 Aug 31. Diabetologia. 2013. PMID: 23995397
Exendin-4 prevents c-Jun N-terminal protein kinase activation by tumor necrosis factor-alpha (TNFalpha) and inhibits TNFalpha-induced apoptosis in insulin-secreting cells.
Natalicchio A, De Stefano F, Orlando MR, Melchiorre M, Leonardini A, Cignarelli A, Labarbuta R, Marchetti P, Perrini S, Laviola L, Giorgino F. Natalicchio A, et al. Among authors: orlando mr. Endocrinology. 2010 May;151(5):2019-29. doi: 10.1210/en.2009-1166. Epub 2010 Mar 10. Endocrinology. 2010. PMID: 20219981
TNFα signals via p66(Shc) to induce E-Selectin, promote leukocyte transmigration and enhance permeability in human endothelial cells.
Laviola L, Orlando MR, Incalza MA, Caccioppoli C, Melchiorre M, Leonardini A, Cignarelli A, Tortosa F, Labarbuta R, Martemucci S, Pacelli C, Cocco T, Perrini S, Natalicchio A, Giorgino F. Laviola L, et al. Among authors: orlando mr. PLoS One. 2013 Dec 2;8(12):e81930. doi: 10.1371/journal.pone.0081930. eCollection 2013. PLoS One. 2013. PMID: 24349153 Free PMC article.
Glucagon-like peptide-1 counteracts oxidative stress-dependent apoptosis of human cardiac progenitor cells by inhibiting the activation of the c-Jun N-terminal protein kinase signaling pathway.
Laviola L, Leonardini A, Melchiorre M, Orlando MR, Peschechera A, Bortone A, Paparella D, Natalicchio A, Perrini S, Giorgino F. Laviola L, et al. Among authors: orlando mr. Endocrinology. 2012 Dec;153(12):5770-81. doi: 10.1210/en.2012-1461. Epub 2012 Oct 17. Endocrinology. 2012. PMID: 23077074
Melkersson-Rosenthal syndrome.
Orlando MR, Atkins JS Jr. Orlando MR, et al. Arch Otolaryngol Head Neck Surg. 1990 Jun;116(6):728-9. doi: 10.1001/archotol.1990.01870060086017. Arch Otolaryngol Head Neck Surg. 1990. PMID: 2160251 Review.