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Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors.
Renaud S, Pugacheva EM, Delgado MD, Braunschweig R, Abdullaev Z, Loukinov D, Benhattar J, Lobanenkov V. Renaud S, et al. Among authors: abdullaev z. Nucleic Acids Res. 2007;35(21):7372-88. doi: 10.1093/nar/gkm896. Epub 2007 Oct 25. Nucleic Acids Res. 2007. PMID: 17962299 Free PMC article.
Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genes.
Vatolin S, Abdullaev Z, Pack SD, Flanagan PT, Custer M, Loukinov DI, Pugacheva E, Hong JA, Morse H 3rd, Schrump DS, Risinger JI, Barrett JC, Lobanenkov VV. Vatolin S, et al. Among authors: abdullaev z. Cancer Res. 2005 Sep 1;65(17):7751-62. doi: 10.1158/0008-5472.CAN-05-0858. Cancer Res. 2005. PMID: 16140943
Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells.
Hong JA, Kang Y, Abdullaev Z, Flanagan PT, Pack SD, Fischette MR, Adnani MT, Loukinov DI, Vatolin S, Risinger JI, Custer M, Chen GA, Zhao M, Nguyen DM, Barrett JC, Lobanenkov VV, Schrump DS. Hong JA, et al. Among authors: abdullaev z. Cancer Res. 2005 Sep 1;65(17):7763-74. doi: 10.1158/0008-5472.CAN-05-0823. Cancer Res. 2005. PMID: 16140944
118 results