Morrell A - Search Results

1

Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance.

Antony S, Agama KK, Miao ZH, Takagi K, Wright MH, Robles AI, Varticovski L, Nagarajan M, Morrell A, Cushman M, Pommier Y. Antony S, et al. Among authors: morrell a. Cancer Res. 2007 Nov 1;67(21):10397-405. doi: 10.1158/0008-5472.CAN-07-0938. Cancer Res. 2007. PMID: 17974983

2

The structure-activity relationships of A-ring-substituted aromathecin topoisomerase I inhibitors strongly support a camptothecin-like binding mode.

Cinelli MA, Morrell AE, Dexheimer TS, Agama K, Agrawal S, Pommier Y, Cushman M. Cinelli MA, et al. Among authors: morrell ae. Bioorg Med Chem. 2010 Aug 1;18(15):5535-52. doi: 10.1016/j.bmc.2010.06.040. Epub 2010 Jun 20. Bioorg Med Chem. 2010. PMID: 20630766 Free PMC article.

3

Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity.

Peterson KE, Cinelli MA, Morrell AE, Mehta A, Dexheimer TS, Agama K, Antony S, Pommier Y, Cushman M. Peterson KE, et al. Among authors: morrell ae. J Med Chem. 2011 Jul 28;54(14):4937-53. doi: 10.1021/jm101338z. Epub 2011 Jun 28. J Med Chem. 2011. PMID: 21710981 Free PMC article.

4

Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors.

Morrell A, Antony S, Kohlhagen G, Pommier Y, Cushman M. Morrell A, et al. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3659-63. doi: 10.1016/j.bmcl.2004.05.022. Bioorg Med Chem Lett. 2004. PMID: 15203138

5

Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay.

Morrell A, Jayaraman M, Nagarajan M, Fox BM, Meckley MR, Ioanoviciu A, Pommier Y, Antony S, Hollingshead M, Cushman M. Morrell A, et al. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4395-9. doi: 10.1016/j.bmcl.2006.05.048. Epub 2006 Jun 5. Bioorg Med Chem Lett. 2006. PMID: 16750365

6

Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity.

Antony S, Agama KK, Miao ZH, Hollingshead M, Holbeck SL, Wright MH, Varticovski L, Nagarajan M, Morrell A, Cushman M, Pommier Y. Antony S, et al. Among authors: morrell a. Mol Pharmacol. 2006 Sep;70(3):1109-20. doi: 10.1124/mol.106.024372. Epub 2006 Jun 23. Mol Pharmacol. 2006. PMID: 16798938

7

Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors.

Nagarajan M, Morrell A, Antony S, Kohlhagen G, Agama K, Pommier Y, Ragazzon PA, Garbett NC, Chaires JB, Hollingshead M, Cushman M. Nagarajan M, et al. Among authors: morrell a. J Med Chem. 2006 Aug 24;49(17):5129-40. doi: 10.1021/jm060046o. J Med Chem. 2006. PMID: 16913702

8

Synthesis and evaluation of indenoisoquinoline topoisomerase I inhibitors substituted with nitrogen heterocycles.

Nagarajan M, Morrell A, Ioanoviciu A, Antony S, Kohlhagen G, Agama K, Hollingshead M, Pommier Y, Cushman M. Nagarajan M, et al. Among authors: morrell a. J Med Chem. 2006 Oct 19;49(21):6283-9. doi: 10.1021/jm060564z. J Med Chem. 2006. PMID: 17034134 Free PMC article.

9

A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor.

Morrell A, Antony S, Kohlhagen G, Pommier Y, Cushman M. Morrell A, et al. J Med Chem. 2006 Dec 28;49(26):7740-53. doi: 10.1021/jm060974n. J Med Chem. 2006. PMID: 17181156 Free PMC article.

10

Investigation of the lactam side chain length necessary for optimal indenoisoquinoline topoisomerase I inhibition and cytotoxicity in human cancer cell cultures.

Morrell A, Placzek MS, Steffen JD, Antony S, Agama K, Pommier Y, Cushman M. Morrell A, et al. J Med Chem. 2007 May 3;50(9):2040-8. doi: 10.1021/jm0613119. Epub 2007 Apr 3. J Med Chem. 2007. PMID: 17402722 Free PMC article.

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