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SCH66336, inhibitor of protein farnesylation, blocks signal transducer and activators of transcription 3 signaling in lung cancer and interacts with a small molecule inhibitor of epidermal growth factor receptor/human epidermal growth factor receptor 2.
Dowlati A, Kluge A, Nethery D, Halmos B, Kern JA. Dowlati A, et al. Among authors: kern ja. Anticancer Drugs. 2008 Jan;19(1):9-16. doi: 10.1097/CAD.0b013e3282f1a908. Anticancer Drugs. 2008. PMID: 18043125
Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity.
Tang Z, Jiang S, Du R, Petri ET, El-Telbany A, Chan PS, Kijima T, Dietrich S, Matsui K, Kobayashi M, Sasada S, Okamoto N, Suzuki H, Kawahara K, Iwasaki T, Nakagawa K, Kawase I, Christensen JG, Hirashima T, Halmos B, Salgia R, Boggon TJ, Kern JA, Ma PC. Tang Z, et al. Among authors: kern ja. Oncogene. 2009 Jan 29;28(4):518-33. doi: 10.1038/onc.2008.411. Epub 2008 Nov 17. Oncogene. 2009. PMID: 19015641 Free PMC article.
Role of mTOR As an Essential Kinase in SCLC.
Kern JA, Kim J, Foster DG, Mishra R, Gardner EE, Poirier JT, Rivard C, Yu H, Finigan JH, Dowlati A, Rudin CM, Tan AC. Kern JA, et al. J Thorac Oncol. 2020 Sep;15(9):1522-1534. doi: 10.1016/j.jtho.2020.05.026. Epub 2020 Jun 26. J Thorac Oncol. 2020. PMID: 32599072 Free PMC article.
357 results