Aurelio L - Search Results

1

5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers.

Aurelio L, Figler H, Flynn BL, Linden J, Scammells PJ. Aurelio L, et al. Bioorg Med Chem. 2008 Feb 1;16(3):1319-27. doi: 10.1016/j.bmc.2007.10.065. Epub 2007 Oct 23. Bioorg Med Chem. 2008. PMID: 17980606

2

Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes.

Aurelio L, Valant C, Flynn BL, Sexton PM, Christopoulos A, Scammells PJ. Aurelio L, et al. J Med Chem. 2009 Jul 23;52(14):4543-7. doi: 10.1021/jm9002582. J Med Chem. 2009. PMID: 19514747

3

3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists.

Aurelio L, Valant C, Figler H, Flynn BL, Linden J, Sexton PM, Christopoulos A, Scammells PJ. Aurelio L, et al. Bioorg Med Chem. 2009 Oct 15;17(20):7353-61. doi: 10.1016/j.bmc.2009.08.024. Epub 2009 Aug 20. Bioorg Med Chem. 2009. PMID: 19751980 Free PMC article.

4

Delineating the mode of action of adenosine A1 receptor allosteric modulators.

Valant C, Aurelio L, Urmaliya VB, White P, Scammells PJ, Sexton PM, Christopoulos A. Valant C, et al. Among authors: aurelio l. Mol Pharmacol. 2010 Sep;78(3):444-55. doi: 10.1124/mol.110.064568. Epub 2010 Jun 14. Mol Pharmacol. 2010. PMID: 20547736

5

Effects of conformational restriction of 2-amino-3-benzoylthiophenes on A(1) adenosine receptor modulation.

Aurelio L, Valant C, Flynn BL, Sexton PM, White JM, Christopoulos A, Scammells PJ. Aurelio L, et al. J Med Chem. 2010 Sep 23;53(18):6550-9. doi: 10.1021/jm1008538. J Med Chem. 2010. PMID: 20806896

6

The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor.

Aurelio L, Christopoulos A, Flynn BL, Scammells PJ, Sexton PM, Valant C. Aurelio L, et al. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3704-7. doi: 10.1016/j.bmcl.2011.04.080. Epub 2011 May 4. Bioorg Med Chem Lett. 2011. PMID: 21612922

7

Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A(1) receptor.

Valant C, Aurelio L, Devine SM, Ashton TD, White JM, Sexton PM, Christopoulos A, Scammells PJ. Valant C, et al. Among authors: aurelio l. J Med Chem. 2012 Mar 8;55(5):2367-75. doi: 10.1021/jm201600e. Epub 2012 Feb 17. J Med Chem. 2012. PMID: 22315963

8

A Structure-Activity Relationship Study of Bitopic N⁶-Substituted Adenosine Derivatives as Biased Adenosine A₁ Receptor Agonists.

Aurelio L, Baltos JA, Ford L, Nguyen ATN, Jörg M, Devine SM, Valant C, White PJ, Christopoulos A, May LT, Scammells PJ. Aurelio L, et al. J Med Chem. 2018 Mar 8;61(5):2087-2103. doi: 10.1021/acs.jmedchem.8b00047. Epub 2018 Feb 23. J Med Chem. 2018. PMID: 29446948

9

New methodology for the N-alkylation of 2-amino-3-acylthiophenes.

Aurelio L, Flynn BL, Scammells PJ. Aurelio L, et al. Org Biomol Chem. 2011 Jul 7;9(13):4886-902. doi: 10.1039/c0ob01156h. Epub 2011 May 11. Org Biomol Chem. 2011. PMID: 21562651

10

Scaffold-divergent synthesis of ring-fused indoles, quinolines, and quinolones via iodonium-induced reaction cascades.

Halim R, Aurelio L, Scammells PJ, Flynn BL. Halim R, et al. Among authors: aurelio l. J Org Chem. 2013 May 17;78(10):4708-18. doi: 10.1021/jo400125p. Epub 2013 May 9. J Org Chem. 2013. PMID: 23659428

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