Wang P - Search Results

1

The mechanism of action of beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine involves a second metabolic pathway leading to beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.

Murakami E, Niu C, Bao H, Micolochick Steuer HM, Whitaker T, Nachman T, Sofia MA, Wang P, Otto MJ, Furman PA. Murakami E, et al. Among authors: wang p. Antimicrob Agents Chemother. 2008 Feb;52(2):458-64. doi: 10.1128/AAC.01184-07. Epub 2007 Nov 12. Antimicrob Agents Chemother. 2008. PMID: 17999967 Free PMC article.

2

PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.

Lam AM, Murakami E, Espiritu C, Steuer HM, Niu C, Keilman M, Bao H, Zennou V, Bourne N, Julander JG, Morrey JD, Smee DF, Frick DN, Heck JA, Wang P, Nagarathnam D, Ross BS, Sofia MJ, Otto MJ, Furman PA. Lam AM, et al. Among authors: wang p. Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96. doi: 10.1128/AAC.00399-10. Epub 2010 Jun 1. Antimicrob Agents Chemother. 2010. PMID: 20516278 Free PMC article.

3

Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

Sofia MJ, Bao D, Chang W, Du J, Nagarathnam D, Rachakonda S, Reddy PG, Ross BS, Wang P, Zhang HR, Bansal S, Espiritu C, Keilman M, Lam AM, Steuer HM, Niu C, Otto MJ, Furman PA. Sofia MJ, et al. Among authors: wang p. J Med Chem. 2010 Oct 14;53(19):7202-18. doi: 10.1021/jm100863x. J Med Chem. 2010. PMID: 20845908

4

A 2'-deoxy-2'-fluoro-2'-C-methyl uridine cyclopentyl carbocyclic analog and its phosphoramidate prodrug as inhibitors of HCV NS5B polymerase.

Liu J, Du J, Wang P, Nagarathnam D, Espiritu CL, Bao H, Murakami E, Furman PA, Sofia MJ. Liu J, et al. Among authors: wang p. Nucleosides Nucleotides Nucleic Acids. 2012 Apr;31(4):277-85. doi: 10.1080/15257770.2012.658131. Nucleosides Nucleotides Nucleic Acids. 2012. PMID: 22444190

5

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.

Wang P, Hollecker L, Pankiewicz KW, Patterson SE, Whitaker T, McBrayer TR, Tharnish PM, Sidwell RW, Stuyver LJ, Otto MJ, Schinazi RF, Watanabe KA. Wang P, et al. J Med Chem. 2004 Nov 18;47(24):6100-3. doi: 10.1021/jm0401210. J Med Chem. 2004. PMID: 15537363

6

Synthesis and structure-activity relationships of novel anti-hepatitis C agents: N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one derivatives.

Wang P, Du J, Rachakonda S, Chun BK, Tharnish PM, Stuyver LJ, Otto MJ, Schinazi RF, Watanabe KA. Wang P, et al. J Med Chem. 2005 Oct 6;48(20):6454-60. doi: 10.1021/jm058223t. J Med Chem. 2005. PMID: 16190771

7

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents.

Wang P, Hollecker L, Pankiewicz KW, Patterson SE, Whitaker T, McBrayer TR, Tharnish PM, Stuyver LJ, Schinazi RF, Otto MJ, Watanabe KA. Wang P, et al. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):957-60. doi: 10.1081/ncn-200059314. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16248071

8

Synthesis and anti-hepatitis C virus activity of nucleoside derivatives of N3, 5'-anhydro-4-(beta-D-ribofuranosyl)-8-aza-purin-2-ones.

Hassan AE, Wang P, McBrayer TR, Tharnish PM, Stuyver LJ, Schinazi RF, Otto MJ, Watanabe KA. Hassan AE, et al. Among authors: wang p. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):961-4. doi: 10.1081/ncn-200059319. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16248072

9

Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.

Chun BK, Wang P, Hassan A, Du J, Tharnish PM, Murakami E, Stuyver L, Otto MJ, Schinazi RF, Watanabe KA. Chun BK, et al. Among authors: wang p. Nucleosides Nucleotides Nucleic Acids. 2007;26(1):83-97. doi: 10.1080/15257770601052307. Nucleosides Nucleotides Nucleic Acids. 2007. PMID: 17162589

10

Phenylpropenamide derivatives: anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs.

Wang P, Naduthambi D, Mosley RT, Niu C, Furman PA, Otto MJ, Sofia MJ. Wang P, et al. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4642-7. doi: 10.1016/j.bmcl.2011.05.077. Epub 2011 Jun 6. Bioorg Med Chem Lett. 2011. PMID: 21704526

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