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Page 1
Selectivity-determining residues in Plk1.
Kothe M, Kohls D, Low S, Coli R, Rennie GR, Feru F, Kuhn C, Ding YH. Kothe M, et al. Chem Biol Drug Des. 2007 Dec;70(6):540-6. doi: 10.1111/j.1747-0285.2007.00594.x. Epub 2007 Nov 13. Chem Biol Drug Des. 2007. PMID: 18005335
Structure of the catalytic domain of human polo-like kinase 1.
Kothe M, Kohls D, Low S, Coli R, Cheng AC, Jacques SL, Johnson TL, Lewis C, Loh C, Nonomiya J, Sheils AL, Verdries KA, Wynn TA, Kuhn C, Ding YH. Kothe M, et al. Biochemistry. 2007 May 22;46(20):5960-71. doi: 10.1021/bi602474j. Epub 2007 Apr 27. Biochemistry. 2007. PMID: 17461553
Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?
Tecle H, Shao J, Li Y, Kothe M, Kazmirski S, Penzotti J, Ding YH, Ohren J, Moshinsky D, Coli R, Jhawar N, Bora E, Jacques-O'Hagan S, Wu J. Tecle H, et al. Among authors: kothe m. Bioorg Med Chem Lett. 2009 Jan 1;19(1):226-9. doi: 10.1016/j.bmcl.2008.10.108. Epub 2008 Oct 31. Bioorg Med Chem Lett. 2009. PMID: 19019675
Novel structural insights for a pair of monoclonal antibodies recognizing non-overlapping epitopes of the glucosyltransferase domain of Clostridium difficile toxin B.
Liu J, Kothe M, Zhang J, Oloo E, Stegalkina S, Mundle ST, Li L, Zhang J, Cole LE, Barone L, Biemann HP, Kleanthous H, Anosova NG, Anderson SF. Liu J, et al. Among authors: kothe m. Curr Res Struct Biol. 2022 Apr 7;4:96-105. doi: 10.1016/j.crstbi.2022.03.003. eCollection 2022. Curr Res Struct Biol. 2022. PMID: 35469152 Free PMC article.
CSF1R signaling is a regulator of pathogenesis in progressive MS.
Hagan N, Kane JL, Grover D, Woodworth L, Madore C, Saleh J, Sancho J, Liu J, Li Y, Proto J, Zelic M, Mahan A, Kothe M, Scholte AA, Fitzgerald M, Gisevius B, Haghikia A, Butovsky O, Ofengeim D. Hagan N, et al. Among authors: kothe m. Cell Death Dis. 2020 Oct 23;11(10):904. doi: 10.1038/s41419-020-03084-7. Cell Death Dis. 2020. PMID: 33097690 Free PMC article.
Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma.
Liu H, Niu D, Tham Sjin RT, Dubrovskiy A, Zhu Z, McDonald JJ, Fahnoe K, Wang Z, Munson M, Scholte A, Barrague M, Fitzgerald M, Liu J, Kothe M, Sun F, Murtie J, Ge J, Rocnik J, Harvey D, Ospina B, Perron K, Zheng G, Shehu E, D'Agostino LA. Liu H, et al. Among authors: kothe m. ACS Med Chem Lett. 2020 Mar 6;11(10):1899-1904. doi: 10.1021/acsmedchemlett.9b00601. eCollection 2020 Oct 8. ACS Med Chem Lett. 2020. PMID: 33062171 Free PMC article.
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