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In vivo CAR T-cell generation in nonhuman primates using lentiviral vectors displaying a multidomain fusion ligand.
Nicolai CJ, Parker MH, Qin J, Tang W, Ulrich-Lewis JT, Gottschalk RJ, Cooper SE, Hernandez Lopez SA, Parrilla D, Mangio RS, Ericson NG, Brandes AH, Umuhoza S, Michels KR, McDonnell MM, Park LY, Shin S, Leung WH, Scharenberg AM, Kiem HP, Larson RP, Beitz LO, Ryu BY. Nicolai CJ, et al. Among authors: scharenberg am. Blood. 2024 Aug 29;144(9):977-987. doi: 10.1182/blood.2024024523. Blood. 2024. PMID: 38861668 Free PMC article.
Addendum to: Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases.
Schmidt MJ, Gupta A, Bednarski C, Gehrig-Giannini S, Richter F, Pitzler C, Gamalinda M, Galonska C, Takeuchi R, Wang K, Reiss C, Dehne K, Lukason MJ, Noma A, Park-Windhol C, Allocca M, Kantardzhieva A, Sane S, Kosakowska K, Cafferty B, Tebbe J, Spencer SJ, Munzer S, Cheng CJ, Scaria A, Scharenberg AM, Cohnen A, Coco WM. Schmidt MJ, et al. Among authors: scharenberg am. Nat Commun. 2023 Jun 13;14(1):3503. doi: 10.1038/s41467-023-39141-w. Nat Commun. 2023. PMID: 37311765 Free PMC article. No abstract available.
A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells.
Cook PJ, Yang SJ, Uenishi GI, Grimm A, West SE, Wang LJ, Jacobs C, Repele A, Drow T, Boukhris A, Dahl NP, Sommer K, Scharenberg AM, Rawlings DJ. Cook PJ, et al. Among authors: scharenberg am. Mol Ther. 2023 Aug 2;31(8):2472-2488. doi: 10.1016/j.ymthe.2023.04.021. Epub 2023 May 4. Mol Ther. 2023. PMID: 37147803 Free PMC article.
Preclinical proof of concept for VivoVec, a lentiviral-based platform for in vivo CAR T-cell engineering.
Michels KR, Sheih A, Hernandez SA, Brandes AH, Parrilla D, Irwin B, Perez AM, Ting HA, Nicolai CJ, Gervascio T, Shin S, Pankau MD, Muhonen M, Freeman J, Gould S, Getto R, Larson RP, Ryu BY, Scharenberg AM, Sullivan AM, Green S. Michels KR, et al. Among authors: scharenberg am. J Immunother Cancer. 2023 Mar;11(3):e006292. doi: 10.1136/jitc-2022-006292. J Immunother Cancer. 2023. PMID: 36918221 Free PMC article.
Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases.
Schmidt MJ, Gupta A, Bednarski C, Gehrig-Giannini S, Richter F, Pitzler C, Gamalinda M, Galonska C, Takeuchi R, Wang K, Reiss C, Dehne K, Lukason MJ, Noma A, Park-Windhol C, Allocca M, Kantardzhieva A, Sane S, Kosakowska K, Cafferty B, Tebbe J, Spencer SJ, Munzer S, Cheng CJ, Scaria A, Scharenberg AM, Cohnen A, Coco WM. Schmidt MJ, et al. Among authors: scharenberg am. Nat Commun. 2021 Jul 9;12(1):4219. doi: 10.1038/s41467-021-24454-5. Nat Commun. 2021. PMID: 34244505 Free PMC article.
Therapeutically relevant engraftment of a CRISPR-Cas9-edited HSC-enriched population with HbF reactivation in nonhuman primates.
Humbert O, Radtke S, Samuelson C, Carrillo RR, Perez AM, Reddy SS, Lux C, Pattabhi S, Schefter LE, Negre O, Lee CM, Bao G, Adair JE, Peterson CW, Rawlings DJ, Scharenberg AM, Kiem HP. Humbert O, et al. Among authors: scharenberg am. Sci Transl Med. 2019 Jul 31;11(503):eaaw3768. doi: 10.1126/scitranslmed.aaw3768. Sci Transl Med. 2019. PMID: 31366580 Free PMC article.
128 results