Batra VK - Search Results

1

(R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta.

McKenna CE, Kashemirov BA, Upton TG, Batra VK, Goodman MF, Pedersen LC, Beard WA, Wilson SH. McKenna CE, et al. Among authors: batra vk. J Am Chem Soc. 2007 Dec 19;129(50):15412-3. doi: 10.1021/ja072127v. Epub 2007 Nov 22. J Am Chem Soc. 2007. PMID: 18031037 Free PMC article. No abstract available.

2

Modifying the beta,gamma leaving-group bridging oxygen alters nucleotide incorporation efficiency, fidelity, and the catalytic mechanism of DNA polymerase beta.

Sucato CA, Upton TG, Kashemirov BA, Batra VK, Martínek V, Xiang Y, Beard WA, Pedersen LC, Wilson SH, McKenna CE, Florián J, Warshel A, Goodman MF. Sucato CA, et al. Among authors: batra vk. Biochemistry. 2007 Jan 16;46(2):461-71. doi: 10.1021/bi061517b. Biochemistry. 2007. PMID: 17209556

3

Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function.

Upton TG, Kashemirov BA, McKenna CE, Goodman MF, Prakash GK, Kultyshev R, Batra VK, Shock DD, Pedersen LC, Beard WA, Wilson SH. Upton TG, et al. Among authors: batra vk. Org Lett. 2009 May 7;11(9):1883-6. doi: 10.1021/ol701755k. Org Lett. 2009. PMID: 19351147 Free PMC article.

4

Halogenated beta,gamma-methylene- and ethylidene-dGTP-DNA ternary complexes with DNA polymerase beta: structural evidence for stereospecific binding of the fluoromethylene analogues.

Batra VK, Pedersen LC, Beard WA, Wilson SH, Kashemirov BA, Upton TG, Goodman MF, McKenna CE. Batra VK, et al. J Am Chem Soc. 2010 Jun 9;132(22):7617-25. doi: 10.1021/ja909370k. J Am Chem Soc. 2010. PMID: 20465217 Free PMC article.

5

Stereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β.

Chamberlain BT, Batra VK, Beard WA, Kadina AP, Shock DD, Kashemirov BA, McKenna CE, Goodman MF, Wilson SH. Chamberlain BT, et al. Among authors: batra vk. Chembiochem. 2012 Mar 5;13(4):528-30. doi: 10.1002/cbic.201100738. Epub 2012 Feb 7. Chembiochem. 2012. PMID: 22315190 Free PMC article.

6

β,γ-CHF- and β,γ-CHCl-dGTP diastereomers: synthesis, discrete 31P NMR signatures, and absolute configurations of new stereochemical probes for DNA polymerases.

Wu Y, Zakharova VM, Kashemirov BA, Goodman MF, Batra VK, Wilson SH, McKenna CE. Wu Y, et al. Among authors: batra vk. J Am Chem Soc. 2012 May 30;134(21):8734-7. doi: 10.1021/ja300218x. Epub 2012 May 18. J Am Chem Soc. 2012. PMID: 22397499 Free PMC article.

7

Amino acid substitution in the active site of DNA polymerase β explains the energy barrier of the nucleotidyl transfer reaction.

Batra VK, Perera L, Lin P, Shock DD, Beard WA, Pedersen LC, Pedersen LG, Wilson SH. Batra VK, et al. J Am Chem Soc. 2013 May 29;135(21):8078-88. doi: 10.1021/ja403842j. Epub 2013 May 16. J Am Chem Soc. 2013. PMID: 23647366 Free PMC article.

8

Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.

Batra VK, Alnajjar KS, Sweasy JB, McKenna CE, Goodman MF, Wilson SH. Batra VK, et al. Biochemistry. 2020 Mar 3;59(8):955-963. doi: 10.1021/acs.biochem.9b01072. Epub 2020 Feb 12. Biochemistry. 2020. PMID: 31999437 Free PMC article.

9

Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate.

Batra VK, Beard WA, Shock DD, Pedersen LC, Wilson SH. Batra VK, et al. Structure. 2005 Aug;13(8):1225-33. doi: 10.1016/j.str.2005.05.010. Structure. 2005. PMID: 16084394 Free article.

10

Magnesium-induced assembly of a complete DNA polymerase catalytic complex.

Batra VK, Beard WA, Shock DD, Krahn JM, Pedersen LC, Wilson SH. Batra VK, et al. Structure. 2006 Apr;14(4):757-66. doi: 10.1016/j.str.2006.01.011. Structure. 2006. PMID: 16615916 Free PMC article.

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