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A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity.
Dong J, Sereno A, Aivazian D, Langley E, Miller BR, Snyder WB, Chan E, Cantele M, Morena R, Joseph IB, Boccia A, Virata C, Gamez J, Yco G, Favis M, Wu X, Graff CP, Wang Q, Rohde E, Rennard R, Berquist L, Huang F, Zhang Y, Gao SX, Ho SN, Demarest SJ, Reff ME, Hariharan K, Glaser SM. Dong J, et al. Among authors: hariharan k. MAbs. 2011 May-Jun;3(3):273-88. doi: 10.4161/mabs.3.3.15188. Epub 2011 May 1. MAbs. 2011. PMID: 21393993 Free PMC article.
Stable IgG-like bispecific antibodies directed toward the type I insulin-like growth factor receptor demonstrate enhanced ligand blockade and anti-tumor activity.
Dong J, Sereno A, Snyder WB, Miller BR, Tamraz S, Doern A, Favis M, Wu X, Tran H, Langley E, Joseph I, Boccia A, Kelly R, Wortham K, Wang Q, Berquist L, Huang F, Gao SX, Zhang Y, Lugovskoy A, Martin S, Gouvis H, Berkowitz S, Chiang G, Reff M, Glaser SM, Hariharan K, Demarest SJ. Dong J, et al. Among authors: hariharan k. J Biol Chem. 2011 Feb 11;286(6):4703-17. doi: 10.1074/jbc.M110.184317. Epub 2010 Dec 1. J Biol Chem. 2011. PMID: 21123183 Free PMC article.
Emerging antibody combinations in oncology.
Demarest SJ, Hariharan K, Dong J. Demarest SJ, et al. Among authors: hariharan k. MAbs. 2011 Jul-Aug;3(4):338-51. doi: 10.4161/mabs.3.4.16615. Epub 2011 Jul 1. MAbs. 2011. PMID: 21697653 Free PMC article. Review.
Modulation of CD47-SIRPα innate immune checkpoint axis with Fc-function detuned anti-CD47 therapeutic antibody.
Narla RK, Modi H, Bauer D, Abbasian M, Leisten J, Piccotti JR, Kopytek S, Eckelman BP, Deveraux Q, Timmer J, Zhu D, Wong L, Escoubet L, Raymon HK, Hariharan K. Narla RK, et al. Among authors: hariharan k. Cancer Immunol Immunother. 2022 Feb;71(2):473-489. doi: 10.1007/s00262-021-03010-6. Epub 2021 Jul 10. Cancer Immunol Immunother. 2022. PMID: 34247273 Free PMC article.
Galiximab signals B-NHL cells and inhibits the activities of NF-κB-induced YY1- and snail-resistant factors: mechanism of sensitization to apoptosis by chemoimmunotherapeutic drugs.
Martinez-Paniagua MA, Vega MI, Huerta-Yepez S, Baritaki S, Vega GG, Hariharan K, Bonavida B. Martinez-Paniagua MA, et al. Among authors: hariharan k. Mol Cancer Ther. 2012 Mar;11(3):572-81. doi: 10.1158/1535-7163.MCT-11-0635. Epub 2012 Jan 19. Mol Cancer Ther. 2012. PMID: 22267549
Rituximab-mediated cell signaling and chemo/immuno-sensitization of drug-resistant B-NHL is independent of its Fc functions.
Vega MI, Huerta-Yepez S, Martinez-Paniagua M, Martinez-Miguel B, Hernandez-Pando R, González-Bonilla CR, Chinn P, Hanna N, Hariharan K, Jazirehi AR, Bonavida B. Vega MI, et al. Among authors: hariharan k. Clin Cancer Res. 2009 Nov 1;15(21):6582-94. doi: 10.1158/1078-0432.CCR-09-1234. Epub 2009 Oct 27. Clin Cancer Res. 2009. PMID: 19861448
108 results