Laufer S - Search Results

1

Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade.

Tavolari S, Bonafè M, Marini M, Ferreri C, Bartolini G, Brighenti E, Manara S, Tomasi V, Laufer S, Guarnieri T. Tavolari S, et al. Among authors: laufer s. Carcinogenesis. 2008 Feb;29(2):371-80. doi: 10.1093/carcin/bgm265. Epub 2007 Nov 21. Carcinogenesis. 2008. PMID: 18033773

2

The decrease of cell membrane fluidity by the non-steroidal anti-inflammatory drug Licofelone inhibits epidermal growth factor receptor signalling and triggers apoptosis in HCA-7 colon cancer cells.

Tavolari S, Munarini A, Storci G, Laufer S, Chieco P, Guarnieri T. Tavolari S, et al. Among authors: laufer s. Cancer Lett. 2012 Aug 28;321(2):187-94. doi: 10.1016/j.canlet.2012.02.003. Epub 2012 Feb 14. Cancer Lett. 2012. PMID: 22343320

3

Licofelone, a novel 5-LOX/COX-inhibitor, attenuates leukocyte rolling and adhesion on endothelium under flow.

Ulbrich H, Soehnlein O, Xie X, Eriksson EE, Lindbom L, Albrecht W, Laufer S, Dannhardt G. Ulbrich H, et al. Among authors: laufer s. Biochem Pharmacol. 2005 Jul 1;70(1):30-6. doi: 10.1016/j.bcp.2005.03.031. Biochem Pharmacol. 2005. PMID: 15894291

4

Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis.

Gay RE, Neidhart M, Pataky F, Tries S, Laufer S, Gay S. Gay RE, et al. Among authors: laufer s. J Rheumatol. 2001 Sep;28(9):2060-5. J Rheumatol. 2001. PMID: 11550975

5

The dual inhibitor of lipoxygenase and cyclooxygenase ML3000 decreases the expression of CXCR3 ligands.

Ospelt C, Kurowska-Stolarska M, Neidhart M, Michel BA, Gay RE, Laufer S, Gay S. Ospelt C, et al. Among authors: laufer s. Ann Rheum Dis. 2008 Apr;67(4):524-9. doi: 10.1136/ard.2007.071589. Epub 2007 Jul 31. Ann Rheum Dis. 2008. PMID: 17666446 Free article.

6

Anti-inflammatory drugs: new multitarget compounds to face an old problem. The dual inhibition concept.

Celotti F, Laufer S. Celotti F, et al. Among authors: laufer s. Pharmacol Res. 2001 May;43(5):429-36. doi: 10.1006/phrs.2000.0784. Pharmacol Res. 2001. PMID: 11394934 Review.

7

The gastrointestinal tolerability of the LOX/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: results from a randomized, controlled trial.

Bias P, Buchner A, Klesser B, Laufer S. Bias P, et al. Among authors: laufer s. Am J Gastroenterol. 2004 Apr;99(4):611-8. doi: 10.1111/j.1572-0241.2004.04133.x. Am J Gastroenterol. 2004. PMID: 15089890 Clinical Trial.

8

Identification of new γ-hydroxybutenolides that preferentially inhibit the activity of mPGES-1.

De Simone R, Bruno I, Riccio R, Stadler K, Bauer J, Schaible AM, Laufer S, Werz O. De Simone R, et al. Among authors: laufer s. Bioorg Med Chem. 2012 Aug 15;20(16):5012-6. doi: 10.1016/j.bmc.2012.06.032. Epub 2012 Jun 23. Bioorg Med Chem. 2012. PMID: 22795900

9

Antithrombotic and platelet function inhibiting effects of ML3000, a new antiinflammatory drug with Cox/5-LOX inhibitory activity.

Tries S, Laufer S, Radziwon P, Breddin HK. Tries S, et al. Among authors: laufer s. Inflamm Res. 2002 Mar;51(3):129-34. doi: 10.1007/pl00000284. Inflamm Res. 2002. PMID: 12005203

10

In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase.

Albrecht W, Unger A, Nussler AK, Laufer S. Albrecht W, et al. Among authors: laufer s. Drug Metab Dispos. 2008 May;36(5):894-903. doi: 10.1124/dmd.108.020347. Epub 2008 Feb 11. Drug Metab Dispos. 2008. PMID: 18268076

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