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Inhibition of mitochondrial protein import by mutant huntingtin.
Yano H, Baranov SV, Baranova OV, Kim J, Pan Y, Yablonska S, Carlisle DL, Ferrante RJ, Kim AH, Friedlander RM. Yano H, et al. Among authors: kim ah, kim j. Nat Neurosci. 2014 Jun;17(6):822-31. doi: 10.1038/nn.3721. Epub 2014 May 18. Nat Neurosci. 2014. PMID: 24836077 Free PMC article.
The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity.
Tourette C, Farina F, Vazquez-Manrique RP, Orfila AM, Voisin J, Hernandez S, Offner N, Parker JA, Menet S, Kim J, Lyu J, Choi SH, Cormier K, Edgerly CK, Bordiuk OL, Smith K, Louise A, Halford M, Stacker S, Vert JP, Ferrante RJ, Lu W, Neri C. Tourette C, et al. Among authors: kim j. PLoS Biol. 2014 Jun 24;12(6):e1001895. doi: 10.1371/journal.pbio.1001895. eCollection 2014 Jun. PLoS Biol. 2014. PMID: 24960609 Free PMC article.
Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis.
Zhang Y, Cook A, Kim J, Baranov SV, Jiang J, Smith K, Cormier K, Bennett E, Browser RP, Day AL, Carlisle DL, Ferrante RJ, Wang X, Friedlander RM. Zhang Y, et al. Among authors: kim j. Neurobiol Dis. 2013 Jul;55:26-35. doi: 10.1016/j.nbd.2013.03.008. Epub 2013 Mar 26. Neurobiol Dis. 2013. PMID: 23537713 Free PMC article.
The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models.
Chopra V, Quinti L, Kim J, Vollor L, Narayanan KL, Edgerly C, Cipicchio PM, Lauver MA, Choi SH, Silverman RB, Ferrante RJ, Hersch S, Kazantsev AG. Chopra V, et al. Among authors: kim j. Cell Rep. 2012 Dec 27;2(6):1492-7. doi: 10.1016/j.celrep.2012.11.001. Epub 2012 Nov 29. Cell Rep. 2012. PMID: 23200855 Free PMC article.
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