Jones LH - Search Results

1

Design and synthesis of a fluorescent muscarinic antagonist.

Jones LH, Randall A, Napier C, Trevethick M, Sreckovic S, Watson J. Jones LH, et al. Bioorg Med Chem Lett. 2008 Jan 15;18(2):825-7. doi: 10.1016/j.bmcl.2007.11.022. Epub 2007 Nov 17. Bioorg Med Chem Lett. 2008. PMID: 18042383

2

A concise and selective synthesis of novel 5-aryloxyimidazole NNRTIs.

Jones LH, Dupont T, Mowbray CE, Newman SD. Jones LH, et al. Org Lett. 2006 Apr 13;8(8):1725-7. doi: 10.1021/ol060316x. Org Lett. 2006. PMID: 16597151

3

Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder.

Pryde DC, Cook AS, Burring DJ, Jones LH, Foll S, Platts MY, Sanderson V, Corless M, Stobie A, Middleton DS, Foster L, Barker L, Van Der Graaf P, Stacey P, Kohl C, Coggon S, Beaumont K. Pryde DC, et al. Among authors: jones lh. Bioorg Med Chem. 2007 Jan 1;15(1):142-59. doi: 10.1016/j.bmc.2006.10.002. Epub 2006 Oct 6. Bioorg Med Chem. 2007. PMID: 17070062

4

Synthetic chemistry-led creation of a difluorinated biaryl ether non-nucleoside reverse transcriptase inhibitor.

Jones LH, Randall A, Barba O, Selby MD. Jones LH, et al. Org Biomol Chem. 2007 Nov 7;5(21):3431-3. doi: 10.1039/b714091f. Epub 2007 Oct 2. Org Biomol Chem. 2007. PMID: 17943200

5

Optimization of 5-aryloxyimidazole non-nucleoside reverse transcriptase inhibitors.

Jones LH, Allan G, Corbau R, Hay D, Middleton DS, Mowbray CE, Newman SD, Perros M, Randall A, Vuong H, Webster R, Westby M, Williams D. Jones LH, et al. ChemMedChem. 2008 Nov;3(11):1756-62. doi: 10.1002/cmdc.200800183. ChemMedChem. 2008. PMID: 18855969

6

Novel indazole non-nucleoside reverse transcriptase inhibitors using molecular hybridization based on crystallographic overlays.

Jones LH, Allan G, Barba O, Burt C, Corbau R, Dupont T, Knöchel T, Irving S, Middleton DS, Mowbray CE, Perros M, Ringrose H, Swain NA, Webster R, Westby M, Phillips C. Jones LH, et al. J Med Chem. 2009 Feb 26;52(4):1219-23. doi: 10.1021/jm801322h. J Med Chem. 2009. PMID: 19175319

7

Pyrazole NNRTIs 3: optimisation of physicochemical properties.

Mowbray CE, Corbau R, Hawes M, Jones LH, Mills JE, Perros M, Selby MD, Stupple PA, Webster R, Wood A. Mowbray CE, et al. Among authors: jones lh. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5603-6. doi: 10.1016/j.bmcl.2009.08.043. Epub 2009 Aug 14. Bioorg Med Chem Lett. 2009. PMID: 19717303

8

Thermodynamic optimisation in drug discovery: a case study using carbonic anhydrase inhibitors.

Scott AD, Phillips C, Alex A, Flocco M, Bent A, Randall A, O'Brien R, Damian L, Jones LH. Scott AD, et al. Among authors: jones lh. ChemMedChem. 2009 Dec;4(12):1985-9. doi: 10.1002/cmdc.200900386. ChemMedChem. 2009. PMID: 19882701 No abstract available.

9

Inhalation by design: dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD.

Jones LH, Baldock H, Bunnage ME, Burrows J, Clarke N, Coghlan M, Entwistle D, Fairman D, Feeder N, Fulton C, Hilton L, James K, Jones RM, Kenyon AS, Marshall S, Newman SD, Osborne R, Patel S, Selby MD, Stuart EF, Trevethick MA, Wright KN, Price DA. Jones LH, et al. Among authors: jones rm. Bioorg Med Chem Lett. 2011 May 1;21(9):2759-63. doi: 10.1016/j.bmcl.2010.10.132. Epub 2010 Oct 31. Bioorg Med Chem Lett. 2011. PMID: 21075627

10

Efficient conversion of a nonselective norepinephrin reuptake inhibitor into a dual muscarinic antagonist-β₂-agonist for the treatment of chronic obstructive pulmonary disease.

Osborne R, Clarke N, Glossop P, Kenyon A, Liu H, Patel S, Summerhill S, Jones LH. Osborne R, et al. Among authors: jones lh. J Med Chem. 2011 Oct 13;54(19):6998-7002. doi: 10.1021/jm2007535. Epub 2011 Sep 2. J Med Chem. 2011. PMID: 21863888

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