Cook JM - Search Results

1

An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models.

Clayton T, Chen JL, Ernst M, Richter L, Cromer BA, Morton CJ, Ng H, Kaczorowski CC, Helmstetter FJ, Furtmüller R, Ecker G, Parker MW, Sieghart W, Cook JM. Clayton T, et al. Among authors: cook jm. Curr Med Chem. 2007;14(26):2755-75. doi: 10.2174/092986707782360097. Curr Med Chem. 2007. PMID: 18045122 Review.

2

Synthesis of novel 2-phenyl-2H-pyrazolo[4,3-c]isoquinolin-3-ols: topological comparisons with analogues of 2-phenyl-2,5-dihydropyrazolo[4,3-c]quinolin-3(3H)-ones at benzodiazepine receptors.

Allen MS, Skolnick P, Cook JM. Allen MS, et al. Among authors: cook jm. J Med Chem. 1992 Jan 24;35(2):368-74. doi: 10.1021/jm00080a024. J Med Chem. 1992. PMID: 1310121

3

Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach.

Allen MS, LaLoggia AJ, Dorn LJ, Martin MJ, Costantino G, Hagen TJ, Koehler KF, Skolnick P, Cook JM. Allen MS, et al. Among authors: cook jm. J Med Chem. 1992 Oct 30;35(22):4001-10. doi: 10.1021/jm00100a004. J Med Chem. 1992. PMID: 1331452

4

Synthetic and computer assisted analysis of the pharmacophore for agonists at benzodiazepine receptors.

Diaz-Arauzo H, Koehler KF, Hagen TJ, Cook JM. Diaz-Arauzo H, et al. Among authors: cook jm. Life Sci. 1991;49(3):207-16. doi: 10.1016/0024-3205(91)90005-v. Life Sci. 1991. PMID: 1648158

5

The agonist pharmacophore of the benzodiazepine receptor. Synthesis of a selective anticonvulsant/anxiolytic.

Diaz-Arauzo H, Evoniuk GE, Skolnick P, Cook JM. Diaz-Arauzo H, et al. Among authors: cook jm. J Med Chem. 1991 May;34(5):1754-6. doi: 10.1021/jm00109a035. J Med Chem. 1991. PMID: 1674542 No abstract available.

6

Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester.

Hollinshead SP, Trudell ML, Skolnick P, Cook JM. Hollinshead SP, et al. Among authors: cook jm. J Med Chem. 1990 Mar;33(3):1062-9. doi: 10.1021/jm00165a028. J Med Chem. 1990. PMID: 1968513

7

Synthesis of substituted 7,12-dihydropyrido[3,2-b:5,4-b']diindoles: rigid planar benzodiazepine receptor ligands with inverse agonist/antagonist properties.

Trudell ML, Lifer SL, Tan YC, Martin MJ, Deng L, Skolnick P, Cook JM. Trudell ML, et al. Among authors: cook jm. J Med Chem. 1990 Sep;33(9):2412-20. doi: 10.1021/jm00171a015. J Med Chem. 1990. PMID: 2167978

8

Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore.

Allen MS, Hagen TJ, Trudell ML, Codding PW, Skolnick P, Cook JM. Allen MS, et al. Among authors: cook jm. J Med Chem. 1988 Sep;31(9):1854-61. doi: 10.1021/jm00117a029. J Med Chem. 1988. PMID: 2842507

9

Development of a comprehensive pharmacophore model for the benzodiazepine receptor.

Zhang W, Koehler KF, Zhang P, Cook JM. Zhang W, et al. Among authors: cook jm. Drug Des Discov. 1995 Jan;12(3):193-248. Drug Des Discov. 1995. PMID: 7662830

10

Synthesis of novel imidazobenzodiazepines as probes of the pharmacophore for "diazepam-insensitive" GABAA receptors.

Zhang P, Zhang W, Liu R, Harris B, Skolnick P, Cook JM. Zhang P, et al. Among authors: cook jm. J Med Chem. 1995 May 12;38(10):1679-88. doi: 10.1021/jm00010a013. J Med Chem. 1995. PMID: 7752192

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