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Multistage designs in the genomic era: providing balance in complex disease studies.
Dubé MP, Schmidt S, Hauser E, Darabi H, Li J, Barhdadi A, Wang X, Sha Q, Zhang Z, Wang T, Aschard H, Guedj M, Rohlfs R, Anderson A, Taylor C, Mirea L, Nickolov R, Milanov V, Yang HC, Song Y, Sinha R. Dubé MP, et al. Among authors: aschard h. Genet Epidemiol. 2007;31 Suppl 1(Suppl 1):S118-23. doi: 10.1002/gepi.20288. Genet Epidemiol. 2007. PMID: 18046769 Free PMC article. Review.
Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.
Scepanovic P, Alanio C, Hammer C, Hodel F, Bergstedt J, Patin E, Thorball CW, Chaturvedi N, Charbit B, Abel L, Quintana-Murci L, Duffy D, Albert ML, Fellay J; Milieu Intérieur Consortium. Scepanovic P, et al. Genome Med. 2018 Jul 27;10(1):59. doi: 10.1186/s13073-018-0568-8. Genome Med. 2018. PMID: 30053915 Free PMC article. Clinical Trial.
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges.
Piasecka B, Duffy D, Urrutia A, Quach H, Patin E, Posseme C, Bergstedt J, Charbit B, Rouilly V, MacPherson CR, Hasan M, Albaud B, Gentien D, Fellay J, Albert ML, Quintana-Murci L; Milieu Intérieur Consortium. Piasecka B, et al. Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E488-E497. doi: 10.1073/pnas.1714765115. Epub 2017 Dec 27. Proc Natl Acad Sci U S A. 2018. PMID: 29282317 Free PMC article.
Identifying COPD subtypes using multi-trait genetics.
Ziyatdinov A, Hobbs BD, Kanaan-Izquierdo S, Moll M, Sakornsakolpat P, Shrine N, Chen J, Song K, Bowler RP, Castaldi PJ, Tobin MD, Kraft P, Silverman EK, Julienne H, Aschard H, Cho MH. Ziyatdinov A, et al. Among authors: aschard h. medRxiv [Preprint]. 2023 Feb 21:2023.02.20.23286186. doi: 10.1101/2023.02.20.23286186. medRxiv. 2023. PMID: 36865145 Free PMC article. Preprint.
A new Approach to Identify Gene-Environment Interactions and Reveal New Biological Insight in Complex traits.
Zhu X, Yang Y, Lorincz-Comi N, Li G, Bentley A, de Vries PS, Brown M, Morrison AC, Rotimi C, James Gauderman W, Rao DC, Aschard H. Zhu X, et al. Among authors: aschard h. Res Sq [Preprint]. 2023 Oct 5:rs.3.rs-3338723. doi: 10.21203/rs.3.rs-3338723/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Apr 22;15(1):3385. doi: 10.1038/s41467-024-47806-3 PMID: 37886448 Free PMC article. Updated. Preprint.
Trait selection strategy in multi-trait GWAS: Boosting SNPs discoverability.
Suzuki Y, Ménager H, Brancotte B, Vernet R, Nerin C, Boetto C, Auvergne A, Linhard C, Torchet R, Lechat P, Troubat L, Cho MH, Bouzigon E, Aschard H, Julienne H. Suzuki Y, et al. Among authors: aschard h. bioRxiv [Preprint]. 2023 Oct 27:2023.10.27.564319. doi: 10.1101/2023.10.27.564319. bioRxiv. 2023. Update in: HGG Adv. 2024 Jul 18;5(3):100319. doi: 10.1016/j.xhgg.2024.100319 PMID: 37961722 Free PMC article. Updated. Preprint.
An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group.
Sung YJ, Winkler TW, Manning AK, Aschard H, Gudnason V, Harris TB, Smith AV, Boerwinkle E, Brown MR, Morrison AC, Fornage M, Lin LA, Richard M, Bartz TM, Psaty BM, Hayward C, Polasek O, Marten J, Rudan I, Feitosa MF, Kraja AT, Province MA, Deng X, Fisher VA, Zhou Y, Bielak LF, Smith J, Huffman JE, Padmanabhan S, Smith BH, Ding J, Liu Y, Lohman K, Bouchard C, Rankinen T, Rice TK, Arnett D, Schwander K, Guo X, Palmas W, Rotter JI, Alfred T, Bottinger EP, Loos RJ, Amin N, Franco OH, van Duijn CM, Vojinovic D, Chasman DI, Ridker PM, Rose LM, Kardia S, Zhu X, Rice K, Borecki IB, Rao DC, Gauderman WJ, Cupples LA. Sung YJ, et al. Among authors: aschard h. Genet Epidemiol. 2016 Jul;40(5):404-15. doi: 10.1002/gepi.21978. Epub 2016 May 27. Genet Epidemiol. 2016. PMID: 27230302 Free PMC article.
136 results