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Development of pyridopyrimidines as potent Akt1/2 inhibitors.
Wu Z, Hartnett JC, Neilson LA, Robinson RG, Fu S, Barnett SF, Defeo-Jones D, Jones RE, Kral AM, Huber HE, Hartman GD, Bilodeau MT. Wu Z, et al. Among authors: defeo jones d. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1274-9. doi: 10.1016/j.bmcl.2008.01.054. Epub 2008 Jan 19. Bioorg Med Chem Lett. 2008. PMID: 18249537
Rapid assembly of diverse and potent allosteric Akt inhibitors.
Wu Z, Robinson RG, Fu S, Barnett SF, Defeo-Jones D, Jones RE, Kral AM, Huber HE, Kohl NE, Hartman GD, Bilodeau MT. Wu Z, et al. Among authors: defeo jones d. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2211-4. doi: 10.1016/j.bmcl.2007.10.023. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2008. PMID: 18296048
Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors.
Siu T, Liang J, Arruda J, Li Y, Jones RE, Defeo-Jones D, Barnett SF, Robinson RG. Siu T, et al. Among authors: defeo jones d. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4186-90. doi: 10.1016/j.bmcl.2008.05.085. Epub 2008 May 24. Bioorg Med Chem Lett. 2008. PMID: 18539456
48 results