Silhár P - Search Results

1

Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides.

Silhár P, Hocek M, Pohl R, Votruba I, Shih IH, Mabery E, Mackman R. Silhár P, et al. Bioorg Med Chem. 2008 Mar 1;16(5):2329-66. doi: 10.1016/j.bmc.2007.11.067. Epub 2007 Nov 29. Bioorg Med Chem. 2008. PMID: 18078757

2

Facile and efficient synthesis of 6-(hydroxymethyl)purines.

Silhár P, Pohl R, Votruba I, Hocek M. Silhár P, et al. Org Lett. 2004 Sep 16;6(19):3225-8. doi: 10.1021/ol049059r. Org Lett. 2004. PMID: 15355018

3

The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides.

Silhár P, Pohl R, Votruba I, Hocek M. Silhár P, et al. Org Biomol Chem. 2005 Aug 21;3(16):3001-7. doi: 10.1039/b508122j. Epub 2005 Jul 4. Org Biomol Chem. 2005. PMID: 16186932

4

Cytostatic and antiviral 6-arylpurine ribonucleosides. Part 7: synthesis and evaluation of 6-substituted purine l-ribonucleosides.

Hocek M, Silhár P, Shih IH, Mabery E, Mackman R. Hocek M, et al. Among authors: silhar p. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5290-3. doi: 10.1016/j.bmcl.2006.07.092. Epub 2006 Aug 14. Bioorg Med Chem Lett. 2006. PMID: 16905315

5

Palladium-catalyzed cross-coupling reactions in c6 modifications of purine nucleosides.

Hocek M, Silhár P. Hocek M, et al. Among authors: silhar p. Curr Protoc Nucleic Acid Chem. 2007 Mar;Chapter 1:Unit 1.16. doi: 10.1002/0471142700.nc0116s28. Curr Protoc Nucleic Acid Chem. 2007. PMID: 18428964

6

Parallel synthesis and nucleic acid binding properties of C(6')-α-functionalized bicyclo-DNA.

Silhár P, Leumann CJ. Silhár P, et al. Bioorg Med Chem. 2010 Nov 15;18(22):7786-93. doi: 10.1016/j.bmc.2010.09.064. Epub 2010 Oct 1. Bioorg Med Chem. 2010. PMID: 20971649

7

Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease.

Šilhár P, Alakurtti S, Čapková K, Xiaochuan F, Shoemaker CB, Yli-Kauhaluoma J, Janda KD. Šilhár P, et al. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2229-31. doi: 10.1016/j.bmcl.2011.02.115. Epub 2011 Mar 4. Bioorg Med Chem Lett. 2011. PMID: 21421315 Free PMC article.

8

Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies.

Šilhár P, Silvaggi NR, Pellett S, Čapková K, Johnson EA, Allen KN, Janda KD. Šilhár P, et al. Bioorg Med Chem. 2013 Mar 1;21(5):1344-8. doi: 10.1016/j.bmc.2012.12.001. Epub 2012 Dec 20. Bioorg Med Chem. 2013. PMID: 23340139 Free PMC article.

9

Examination of α-exosite inhibitors against Botulinum neurotoxin A protease through structure-activity relationship studies of chicoric acid.

Xue S, Seki H, Remes M, Šilhár P, Janda K. Xue S, et al. Among authors: silhar p. Bioorg Med Chem Lett. 2017 Nov 15;27(22):4956-4959. doi: 10.1016/j.bmcl.2017.10.021. Epub 2017 Oct 12. Bioorg Med Chem Lett. 2017. PMID: 29050781 Free PMC article.

10

Highly beta-selective, N-iodosuccinimide-mediated nucleosidation to bicyclo- and tricyclo-nucleosides.

Luisier S, Silhar P, Leumann CJ. Luisier S, et al. Among authors: silhar p. Nucleic Acids Symp Ser (Oxf). 2008;(52):581-2. doi: 10.1093/nass/nrn294. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776513

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