An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus.
DeLuca GC, Ramagopalan SV, Herrera BM, Dyment DA, Lincoln MR, Montpetit A, Pugliatti M, Barnardo MC, Risch NJ, Sadovnick AD, Chao M, Sotgiu S, Hudson TJ, Ebers GC.
DeLuca GC, et al. Among authors: pugliatti m.
Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20896-901. doi: 10.1073/pnas.0707731105. Epub 2007 Dec 17.
Proc Natl Acad Sci U S A. 2007.
PMID: 18087043
Free PMC article.