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Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F.
Kuestner RE, Taft DW, Haran A, Brandt CS, Brender T, Lum K, Harder B, Okada S, Ostrander CD, Kreindler JL, Aujla SJ, Reardon B, Moore M, Shea P, Schreckhise R, Bukowski TR, Presnell S, Guerra-Lewis P, Parrish-Novak J, Ellsworth JL, Jaspers S, Lewis KE, Appleby M, Kolls JK, Rixon M, West JW, Gao Z, Levin SD. Kuestner RE, et al. Among authors: lewis ke. J Immunol. 2007 Oct 15;179(8):5462-73. doi: 10.4049/jimmunol.179.8.5462. J Immunol. 2007. PMID: 17911633 Free PMC article.
Engineering of stable bispecific antibodies targeting IL-17A and IL-23.
Mabry R, Lewis KE, Moore M, McKernan PA, Bukowski TR, Bontadelli K, Brender T, Okada S, Lum K, West J, Kuijper JL, Ardourel D, Franke S, Lockwood L, Vu T, Frank A, Appleby MW, Wolf A, Reardon B, Hamacher NB, Stevens B, Lewis P, Lewis KB, Gilbertson DG, Lantry M, Julien SH, Ostrander C, Chan C, Byrnes-Blake K, Brody J, Presnell S, Meengs B, Levin SD, Snavely M. Mabry R, et al. Among authors: lewis p, lewis ke, lewis kb. Protein Eng Des Sel. 2010 Mar;23(3):115-27. doi: 10.1093/protein/gzp073. Epub 2009 Dec 18. Protein Eng Des Sel. 2010. PMID: 20022918
Vstm3 is a member of the CD28 family and an important modulator of T-cell function.
Levin SD, Taft DW, Brandt CS, Bucher C, Howard ED, Chadwick EM, Johnston J, Hammond A, Bontadelli K, Ardourel D, Hebb L, Wolf A, Bukowski TR, Rixon MW, Kuijper JL, Ostrander CD, West JW, Bilsborough J, Fox B, Gao Z, Xu W, Ramsdell F, Blazar BR, Lewis KE. Levin SD, et al. Among authors: lewis ke. Eur J Immunol. 2011 Apr;41(4):902-15. doi: 10.1002/eji.201041136. Epub 2011 Mar 18. Eur J Immunol. 2011. PMID: 21416464 Free PMC article.
The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity.
Maurer MF, Lewis KE, Kuijper JL, Ardourel D, Gudgeon CJ, Chandrasekaran S, Mudri SL, Kleist KN, Navas C, Wolfson MF, Rixon MW, Swanson R, Dillon SR, Levin SD, Kimbung YR, Akutsu M, Logan DT, Walse B, Swiderek KM, Peng SL. Maurer MF, et al. Among authors: lewis ke. Nat Commun. 2022 Apr 4;13(1):1790. doi: 10.1038/s41467-022-29286-5. Nat Commun. 2022. PMID: 35379805 Free PMC article.
Novel Immunomodulatory Proteins Generated via Directed Evolution of Variant IgSF Domains.
Levin SD, Evans LS, Bort S, Rickel E, Lewis KE, Wu RP, Hoover J, MacNeil S, La D, Wolfson MF, Rixon MW, Dillon SR, Kornacker MG, Swanson R, Peng SL. Levin SD, et al. Among authors: lewis ke. Front Immunol. 2020 Jan 21;10:3086. doi: 10.3389/fimmu.2019.03086. eCollection 2019. Front Immunol. 2020. PMID: 32038630 Free PMC article.
223 results