Lee FY - Search Results

1

BMS-214662 potently induces apoptosis of chronic myeloid leukemia stem and progenitor cells and synergizes with tyrosine kinase inhibitors.

Copland M, Pellicano F, Richmond L, Allan EK, Hamilton A, Lee FY, Weinmann R, Holyoake TL. Copland M, et al. Among authors: lee fy. Blood. 2008 Mar 1;111(5):2843-53. doi: 10.1182/blood-2007-09-112573. Epub 2007 Dec 21. Blood. 2008. PMID: 18156496 Free article.

2

Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice.

Hu Y, Swerdlow S, Duffy TM, Weinmann R, Lee FY, Li S. Hu Y, et al. Among authors: lee fy. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16870-5. doi: 10.1073/pnas.0606509103. Epub 2006 Oct 31. Proc Natl Acad Sci U S A. 2006. PMID: 17077147 Free PMC article.

3

Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: high efficacy of drug combinations.

Bradeen HA, Eide CA, O'Hare T, Johnson KJ, Willis SG, Lee FY, Druker BJ, Deininger MW. Bradeen HA, et al. Among authors: lee fy. Blood. 2006 Oct 1;108(7):2332-8. doi: 10.1182/blood-2006-02-004580. Epub 2006 Jun 13. Blood. 2006. PMID: 16772610 Free PMC article.

4

Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients.

Lu KV, Zhu S, Cvrljevic A, Huang TT, Sarkaria S, Ahkavan D, Dang J, Dinca EB, Plaisier SB, Oderberg I, Lee Y, Chen Z, Caldwell JS, Xie Y, Loo JA, Seligson D, Chakravari A, Lee FY, Weinmann R, Cloughesy TF, Nelson SF, Bergers G, Graeber T, Furnari FB, James CD, Cavenee WK, Johns TG, Mischel PS. Lu KV, et al. Among authors: lee y, lee fy. Cancer Res. 2009 Sep 1;69(17):6889-98. doi: 10.1158/0008-5472.CAN-09-0347. Epub 2009 Aug 18. Cancer Res. 2009. PMID: 19690143 Free PMC article.

5

Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis.

Shah NP, Lee FY, Luo R, Jiang Y, Donker M, Akin C. Shah NP, et al. Among authors: lee fy. Blood. 2006 Jul 1;108(1):286-91. doi: 10.1182/blood-2005-10-3969. Epub 2006 Jan 24. Blood. 2006. PMID: 16434489 Free article.

6

Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia.

Porkka K, Koskenvesa P, Lundán T, Rimpiläinen J, Mustjoki S, Smykla R, Wild R, Luo R, Arnan M, Brethon B, Eccersley L, Hjorth-Hansen H, Höglund M, Klamova H, Knutsen H, Parikh S, Raffoux E, Gruber F, Brito-Babapulle F, Dombret H, Duarte RF, Elonen E, Paquette R, Zwaan CM, Lee FY. Porkka K, et al. Among authors: lee fy. Blood. 2008 Aug 15;112(4):1005-12. doi: 10.1182/blood-2008-02-140665. Epub 2008 May 13. Blood. 2008. PMID: 18477770 Free article. Clinical Trial.

7

Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival.

Song L, Morris M, Bagui T, Lee FY, Jove R, Haura EB. Song L, et al. Among authors: lee fy. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620. Cancer Res. 2006. PMID: 16740687

8

Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells.

Nam S, Williams A, Vultur A, List A, Bhalla K, Smith D, Lee FY, Jove R. Nam S, et al. Among authors: lee fy. Mol Cancer Ther. 2007 Apr;6(4):1400-5. doi: 10.1158/1535-7163.MCT-06-0446. Mol Cancer Ther. 2007. PMID: 17431118

9

Overcoming kinase resistance in chronic myeloid leukemia.

Lee F, Fandi A, Voi M. Lee F, et al. Int J Biochem Cell Biol. 2008;40(3):334-43. doi: 10.1016/j.biocel.2007.10.001. Int J Biochem Cell Biol. 2008. PMID: 18401881 Review.

10

In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants.

O'Hare T, Walters DK, Stoffregen EP, Jia T, Manley PW, Mestan J, Cowan-Jacob SW, Lee FY, Heinrich MC, Deininger MW, Druker BJ. O'Hare T, et al. Among authors: lee fy. Cancer Res. 2005 Jun 1;65(11):4500-5. doi: 10.1158/0008-5472.CAN-05-0259. Cancer Res. 2005. PMID: 15930265

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