Bridal TR - Search Results

1

Design and SAR of selective T-type calcium channel antagonists containing a biaryl sulfonamide core.

Hangeland JJ, Cheney DL, Friends TJ, Swartz S, Levesque PC, Rich AJ, Sun L, Bridal TR, Adam LP, Normandin DE, Murugesan N, Ewing WR. Hangeland JJ, et al. Among authors: bridal tr. Bioorg Med Chem Lett. 2008 Jan 15;18(2):474-8. doi: 10.1016/j.bmcl.2007.11.103. Epub 2007 Dec 3. Bioorg Med Chem Lett. 2008. PMID: 18160281

2

T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.

Smith EM, Sorota S, Kim HM, McKittrick BA, Nechuta TL, Bennett C, Knutson C, Burnett DA, Kieselgof J, Tan Z, Rindgen D, Bridal T, Zhou X, Jia YP, Dong Z, Mullins D, Zhang X, Priestley T, Correll CC, Tulshian D, Czarniecki M, Greenlee WJ. Smith EM, et al. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4602-6. doi: 10.1016/j.bmcl.2010.06.012. Epub 2010 Jun 8. Bioorg Med Chem Lett. 2010. PMID: 20580233

3

Bioavailable pyrrolo-benzo-1,4-diazines as Na(v)1.7 sodium channel blockers for the treatment of pain.

Yang SW, Ho GD, Tulshian D, Bercovici A, Tan Z, Hanisak J, Brumfield S, Matasi J, Sun X, Sakwa SA, Herr RJ, Zhou X, Bridal T, Urban M, Vivian J, Rindgen D, Sorota S. Yang SW, et al. Bioorg Med Chem Lett. 2014 Nov 1;24(21):4958-62. doi: 10.1016/j.bmcl.2014.09.038. Epub 2014 Sep 19. Bioorg Med Chem Lett. 2014. PMID: 25288187

4

Discovery of pyrrolo-benzo-1,4-diazines as potent Na(v)1.7 sodium channel blockers.

Ho GD, Tulshian D, Bercovici A, Tan Z, Hanisak J, Brumfield S, Matasi J, Heap CR, Earley WG, Courneya B, Herr RJ, Zhou X, Bridal T, Rindgen D, Sorota S, Yang SW. Ho GD, et al. Bioorg Med Chem Lett. 2014 Sep 1;24(17):4110-3. doi: 10.1016/j.bmcl.2014.07.060. Epub 2014 Jul 29. Bioorg Med Chem Lett. 2014. PMID: 25113934

5

Block of the delayed rectifier current (IK) by the 5-HT3 antagonists ondansetron and granisetron in feline ventricular myocytes.

de Lorenzi FG, Bridal TR, Spinelli W. de Lorenzi FG, et al. Among authors: bridal tr. Br J Pharmacol. 1994 Oct;113(2):527-35. doi: 10.1111/j.1476-5381.1994.tb17021.x. Br J Pharmacol. 1994. PMID: 7834204 Free PMC article.

6

Comparison of human Ether-à-go-go related gene screening assays based on IonWorks Quattro and thallium flux.

Bridal TR, Margulis M, Wang X, Donio M, Sorota S. Bridal TR, et al. Assay Drug Dev Technol. 2010 Dec;8(6):755-65. doi: 10.1089/adt.2010.0267. Epub 2010 Jul 26. Assay Drug Dev Technol. 2010. PMID: 20658944

7

Voltage-dependent inhibition of the ATP-sensitive K+ current by the class Ia agent disopyramide in cat ventricular myocytes.

de Lorenzi FG, Bridal TR, Spinelli W. de Lorenzi FG, et al. Among authors: bridal tr. J Pharmacol Exp Ther. 1995 Feb;272(2):714-23. J Pharmacol Exp Ther. 1995. PMID: 7853185

8

Inhibition of cardiac delayed rectifier K+ current by overexpression of the long-QT syndrome HERG G628S mutation in transgenic mice.

Babij P, Askew GR, Nieuwenhuijsen B, Su CM, Bridal TR, Jow B, Argentieri TM, Kulik J, DeGennaro LJ, Spinelli W, Colatsky TJ. Babij P, et al. Among authors: bridal tr. Circ Res. 1998 Sep 21;83(6):668-78. doi: 10.1161/01.res.83.6.668. Circ Res. 1998. PMID: 9742063

9

Sphingosine modulates myocyte electrophysiology, induces negative inotropy, and decreases survival after myocardial ischemia.

Friedrichs GS, Swillo RE, Jow B, Bridal T, Numann R, Warner LM, Killar LM, Sidek K. Friedrichs GS, et al. J Cardiovasc Pharmacol. 2002 Jan;39(1):18-28. doi: 10.1097/00005344-200201000-00003. J Cardiovasc Pharmacol. 2002. PMID: 11743224

10

Inhibition of gramicidin channel activity by local anesthetics.

Bridal TR, Busath D. Bridal TR, et al. Biochim Biophys Acta. 1992 Jun 11;1107(1):31-8. doi: 10.1016/0005-2736(92)90325-g. Biochim Biophys Acta. 1992. PMID: 1377493

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