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Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum.
Chiang AN, Valderramos JC, Balachandran R, Chovatiya RJ, Mead BP, Schneider C, Bell SL, Klein MG, Huryn DM, Chen XS, Day BW, Fidock DA, Wipf P, Brodsky JL. Chiang AN, et al. Among authors: huryn dm. Bioorg Med Chem. 2009 Feb 15;17(4):1527-33. doi: 10.1016/j.bmc.2009.01.024. Epub 2009 Jan 20. Bioorg Med Chem. 2009. PMID: 19195901 Free PMC article.
2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway.
LaPorte MG, da Paz Lima DJ, Zhang F, Sen M, Grandis JR, Camarco D, Hua Y, Johnston PA, Lazo JS, Resnick LO, Wipf P, Huryn DM. LaPorte MG, et al. Among authors: huryn dm. Bioorg Med Chem Lett. 2014 Nov 1;24(21):5081-5. doi: 10.1016/j.bmcl.2014.09.001. Epub 2014 Sep 15. Bioorg Med Chem Lett. 2014. PMID: 25288188 Free PMC article.
Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97.
Alverez C, Arkin MR, Bulfer SL, Colombo R, Kovaliov M, LaPorte MG, Lim C, Liang M, Moore WJ, Neitz RJ, Yan Y, Yue Z, Huryn DM, Wipf P. Alverez C, et al. Among authors: huryn dm. ACS Med Chem Lett. 2015 Oct 23;6(12):1225-30. doi: 10.1021/acsmedchemlett.5b00364. eCollection 2015 Dec 10. ACS Med Chem Lett. 2015. PMID: 26713109 Free PMC article.
2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition.
Banerjee S, Bartesaghi A, Merk A, Rao P, Bulfer SL, Yan Y, Green N, Mroczkowski B, Neitz RJ, Wipf P, Falconieri V, Deshaies RJ, Milne JL, Huryn D, Arkin M, Subramaniam S. Banerjee S, et al. Science. 2016 Feb 19;351(6275):871-5. doi: 10.1126/science.aad7974. Epub 2016 Jan 28. Science. 2016. PMID: 26822609 Free PMC article.
92 results