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Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.
Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. Mallari JP, et al. Among authors: greenbaum d. J Med Chem. 2008 Feb 14;51(3):545-52. doi: 10.1021/jm070760l. Epub 2008 Jan 4. J Med Chem. 2008. PMID: 18173229
Recent studies have shown that a cathepsin B like protease, TbcatB, is essential to the survival of T. brucei in vitro (Mackey, Z. B.; O'Brien, T. C.; Greenbaum, D. C.; Blank, R. B.; McKerrow, J. H. J. Biol. Chem. 2004, 279, 48426-48433). ...
Recent studies have shown that a cathepsin B like protease, TbcatB, is essential to the survival of T. brucei in vitro (Mackey, Z. B.; O'Bri …
The Trypanosoma cruzi protease cruzain mediates immune evasion.
Doyle PS, Zhou YM, Hsieh I, Greenbaum DC, McKerrow JH, Engel JC. Doyle PS, et al. PLoS Pathog. 2011 Sep;7(9):e1002139. doi: 10.1371/journal.ppat.1002139. Epub 2011 Sep 1. PLoS Pathog. 2011. PMID: 21909255 Free PMC article.
237 results