Harbut M - Search Results

1

Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB.

Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. Mallari JP, et al. Among authors: harbut m. J Med Chem. 2008 Feb 14;51(3):545-52. doi: 10.1021/jm070760l. Epub 2008 Jan 4. J Med Chem. 2008. PMID: 18173229

2

Development of bestatin-based activity-based probes for metallo-aminopeptidases.

Harbut MB, Velmourougane G, Reiss G, Chandramohanadas R, Greenbaum DC. Harbut MB, et al. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5932-6. doi: 10.1016/j.bmcl.2008.09.021. Epub 2008 Sep 10. Bioorg Med Chem Lett. 2008. PMID: 18823778 Free PMC article.

3

Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase.

Velmourougane G, Harbut MB, Dalal S, McGowan S, Oellig CA, Meinhardt N, Whisstock JC, Klemba M, Greenbaum DC. Velmourougane G, et al. Among authors: harbut mb. J Med Chem. 2011 Mar 24;54(6):1655-66. doi: 10.1021/jm101227t. Epub 2011 Mar 2. J Med Chem. 2011. PMID: 21366301 Free PMC article.

4

Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design.

Harbut MB, Patel BA, Yeung BK, McNamara CW, Bright AT, Ballard J, Supek F, Golde TE, Winzeler EA, Diagana TT, Greenbaum DC. Harbut MB, et al. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21486-91. doi: 10.1073/pnas.1216016110. Epub 2012 Dec 11. Proc Natl Acad Sci U S A. 2012. PMID: 23236186 Free PMC article.

5

Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells.

Chandramohanadas R, Davis PH, Beiting DP, Harbut MB, Darling C, Velmourougane G, Lee MY, Greer PA, Roos DS, Greenbaum DC. Chandramohanadas R, et al. Science. 2009 May 8;324(5928):794-7. doi: 10.1126/science.1171085. Epub 2009 Apr 2. Science. 2009. PMID: 19342550 Free PMC article.

6

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases.

Harbut MB, Velmourougane G, Dalal S, Reiss G, Whisstock JC, Onder O, Brisson D, McGowan S, Klemba M, Greenbaum DC. Harbut MB, et al. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E526-34. doi: 10.1073/pnas.1105601108. Epub 2011 Aug 15. Proc Natl Acad Sci U S A. 2011. PMID: 21844374 Free PMC article.

7

Replication bypass of interstrand cross-link intermediates by Escherichia coli DNA polymerase IV.

Kumari A, Minko IG, Harbut MB, Finkel SE, Goodman MF, Lloyd RS. Kumari A, et al. J Biol Chem. 2008 Oct 10;283(41):27433-27437. doi: 10.1074/jbc.M801237200. Epub 2008 Aug 11. J Biol Chem. 2008. PMID: 18697749 Free PMC article.

8

Role for DNA polymerase kappa in the processing of N2-N2-guanine interstrand cross-links.

Minko IG, Harbut MB, Kozekov ID, Kozekova A, Jakobs PM, Olson SB, Moses RE, Harris TM, Rizzo CJ, Lloyd RS. Minko IG, et al. Among authors: harbut mb. J Biol Chem. 2008 Jun 20;283(25):17075-82. doi: 10.1074/jbc.M801238200. Epub 2008 Apr 22. J Biol Chem. 2008. PMID: 18434313 Free PMC article.

9

Replication bypass of N2-deoxyguanosine interstrand cross-links by human DNA polymerases η and ι.

Klug AR, Harbut MB, Lloyd RS, Minko IG. Klug AR, et al. Among authors: harbut mb. Chem Res Toxicol. 2012 Mar 19;25(3):755-62. doi: 10.1021/tx300011w. Epub 2012 Feb 29. Chem Res Toxicol. 2012. PMID: 22332732 Free PMC article.

10

Modulation of the turnover of formamidopyrimidine DNA glycosylase.

Harbut MB, Meador M, Dodson ML, Lloyd RS. Harbut MB, et al. Biochemistry. 2006 Jun 13;45(23):7341-6. doi: 10.1021/bi052383p. Biochemistry. 2006. PMID: 16752923 Free PMC article.

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