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395 results

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Page 1
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.
Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P. Aragonés J, et al. Among authors: ratcliffe p. Nat Genet. 2008 Feb;40(2):170-80. doi: 10.1038/ng.2007.62. Epub 2008 Jan 6. Nat Genet. 2008. PMID: 18176562 Free article.
Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury.
Schneider M, Van Geyte K, Fraisl P, Kiss J, Aragonés J, Mazzone M, Mairbäurl H, De Bock K, Jeoung NH, Mollenhauer M, Georgiadou M, Bishop T, Roncal C, Sutherland A, Jordan B, Gallez B, Weitz J, Harris RA, Maxwell P, Baes M, Ratcliffe P, Carmeliet P. Schneider M, et al. Among authors: ratcliffe p. Gastroenterology. 2010 Mar;138(3):1143-54.e1-2. doi: 10.1053/j.gastro.2009.09.057. Epub 2009 Oct 8. Gastroenterology. 2010. PMID: 19818783 Free article.
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.
Mazzone M, Dettori D, de Oliveira RL, Loges S, Schmidt T, Jonckx B, Tian YM, Lanahan AA, Pollard P, de Almodovar CR, De Smet F, Vinckier S, Aragonés J, Debackere K, Luttun A, Wyns S, Jordan B, Pisacane A, Gallez B, Lampugnani MG, Dejana E, Simons M, Ratcliffe P, Maxwell P, Carmeliet P. Mazzone M, et al. Among authors: ratcliffe p. Cell. 2009 Mar 6;136(5):839-851. doi: 10.1016/j.cell.2009.01.020. Epub 2009 Feb 12. Cell. 2009. PMID: 19217150 Free PMC article.
Activation of the HIF pathway in cancer.
Maxwell PH, Pugh CW, Ratcliffe PJ. Maxwell PH, et al. Among authors: ratcliffe pj. Curr Opin Genet Dev. 2001 Jun;11(3):293-9. doi: 10.1016/s0959-437x(00)00193-3. Curr Opin Genet Dev. 2001. PMID: 11377966 Review.
Oxygen sensors and angiogenesis.
Maxwell PH, Ratcliffe PJ. Maxwell PH, et al. Semin Cell Dev Biol. 2002 Feb;13(1):29-37. doi: 10.1006/scdb.2001.0287. Semin Cell Dev Biol. 2002. PMID: 11969369 Review.
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice.
Bishop T, Gallagher D, Pascual A, Lygate CA, de Bono JP, Nicholls LG, Ortega-Saenz P, Oster H, Wijeyekoon B, Sutherland AI, Grosfeld A, Aragones J, Schneider M, van Geyte K, Teixeira D, Diez-Juan A, Lopez-Barneo J, Channon KM, Maxwell PH, Pugh CW, Davies AM, Carmeliet P, Ratcliffe PJ. Bishop T, et al. Among authors: ratcliffe pj. Mol Cell Biol. 2008 May;28(10):3386-400. doi: 10.1128/MCB.02041-07. Epub 2008 Mar 10. Mol Cell Biol. 2008. PMID: 18332118 Free PMC article.
Beyond erythropoietin: the oxygen sensor.
Ratcliffe PJ, Maxwell PH, Pugh CW. Ratcliffe PJ, et al. Nephrol Dial Transplant. 1997 Sep;12(9):1842-8. doi: 10.1093/ndt/12.9.1842. Nephrol Dial Transplant. 1997. PMID: 9306333 Review. No abstract available.
395 results