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Peripherally restricted oxytocin is sufficient to reduce food intake and motivation, while CNS entry is required for locomotor and taste avoidance effects.
Asker M, Krieger JP, Liles A, Tinsley IC, Borner T, Maric I, Doebley S, Furst CD, Börchers S, Longo F, Bhat YR, De Jonghe BC, Hayes MR, Doyle RP, Skibicka KP. Asker M, et al. Among authors: de jonghe bc. Diabetes Obes Metab. 2023 Mar;25(3):856-877. doi: 10.1111/dom.14937. Epub 2023 Jan 9. Diabetes Obes Metab. 2023. PMID: 36495318 Free PMC article.
Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types.
Salimando GJ, Tremblay S, Kimmey BA, Li J, Rogers SA, Wojick JA, McCall NM, Wooldridge LM, Rodrigues A, Borner T, Gardiner KL, Jayakar SS, Singeç I, Woolf CJ, Hayes MR, De Jonghe BC, Bennett FC, Bennett ML, Blendy JA, Platt ML, Creasy KT, Renthal WR, Ramakrishnan C, Deisseroth K, Corder G. Salimando GJ, et al. Among authors: de jonghe bc. Nat Commun. 2023 Sep 13;14(1):5632. doi: 10.1038/s41467-023-41407-2. Nat Commun. 2023. PMID: 37704594 Free PMC article.
The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1.
Hayes MR, Kanoski SE, De Jonghe BC, Leichner TM, Alhadeff AL, Fortin SM, Arnold M, Langhans W, Grill HJ. Hayes MR, et al. Among authors: de jonghe bc. Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1479-85. doi: 10.1152/ajpregu.00356.2011. Epub 2011 Aug 17. Am J Physiol Regul Integr Comp Physiol. 2011. PMID: 21849636 Free PMC article.
GDF15 Induces Anorexia through Nausea and Emesis.
Borner T, Shaulson ED, Ghidewon MY, Barnett AB, Horn CC, Doyle RP, Grill HJ, Hayes MR, De Jonghe BC. Borner T, et al. Among authors: de jonghe bc. Cell Metab. 2020 Feb 4;31(2):351-362.e5. doi: 10.1016/j.cmet.2019.12.004. Epub 2020 Jan 9. Cell Metab. 2020. PMID: 31928886 Free PMC article.
A second-generation glucagon-like peptide-1 receptor agonist mitigates vomiting and anorexia while retaining glucoregulatory potency in lean diabetic and emetic mammalian models.
Borner T, Shaulson ED, Tinsley IC, Stein LM, Horn CC, Hayes MR, Doyle RP, De Jonghe BC. Borner T, et al. Among authors: de jonghe bc. Diabetes Obes Metab. 2020 Oct;22(10):1729-1741. doi: 10.1111/dom.14089. Epub 2020 Jun 25. Diabetes Obes Metab. 2020. PMID: 32410372 Free PMC article.
58 results