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Practical approach for the identification and isomer elucidation of biomarkers detected in a metabonomic study for the discovery of individuals at risk for diabetes by integrating the chromatographic and mass spectrometric information.
Chen J, Zhao X, Fritsche J, Yin P, Schmitt-Kopplin P, Wang W, Lu X, Häring HU, Schleicher ED, Lehmann R, Xu G. Chen J, et al. Among authors: fritsche j. Anal Chem. 2008 Feb 15;80(4):1280-9. doi: 10.1021/ac702089h. Epub 2008 Jan 15. Anal Chem. 2008. PMID: 18193893
Metabonomics study on the effects of the ginsenoside Rg3 in a beta-cyclodextrin-based formulation on tumor-bearing rats by a fully automatic hydrophilic interaction/reversed-phase column-switching HPLC-ESI-MS approach.
Wang Y, Wang J, Yao M, Zhao X, Fritsche J, Schmitt-Kopplin P, Cai Z, Wan D, Lu X, Yang S, Gu J, Häring HU, Schleicher ED, Lehmann R, Xu G. Wang Y, et al. Among authors: fritsche j. Anal Chem. 2008 Jun 15;80(12):4680-8. doi: 10.1021/ac8002402. Epub 2008 May 9. Anal Chem. 2008. PMID: 18465884
Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidation.
Lehmann R, Zhao X, Weigert C, Simon P, Fehrenbach E, Fritsche J, Machann J, Schick F, Wang J, Hoene M, Schleicher ED, Häring HU, Xu G, Niess AM. Lehmann R, et al. Among authors: fritsche j. PLoS One. 2010 Jul 12;5(7):e11519. doi: 10.1371/journal.pone.0011519. PLoS One. 2010. PMID: 20634953 Free PMC article. Clinical Trial.
HtrA1 prevents and reverses α-synuclein aggregation, rendering it non-toxic and seeding incompetent.
Chen S, Puri A, Bell B, Fritsche J, Palacios H, Balch M, Sprunger M, Howard M, Patterson J, Patti G, Davis A, Jackrel M. Chen S, et al. Among authors: fritsche j. Res Sq [Preprint]. 2023 Aug 22:rs.3.rs-2570571. doi: 10.21203/rs.3.rs-2570571/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Mar 18;15(1):2436. doi: 10.1038/s41467-024-46538-8 PMID: 37674720 Free PMC article. Updated. Preprint.
82 results