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Bioisosteric replacement of dihydropyrazole of 4S-(-)-3-(4-chlorophenyl)-N-methyl-N'-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole.
Srivastava BK, Soni R, Joharapurkar A, Sairam KV, Patel JZ, Goswami A, Shedage SA, Kar SS, Salunke RP, Gugale SB, Dhawas A, Kadam P, Mishra B, Sadhwani N, Unadkat VB, Mitra P, Jain MR, Patel PR. Srivastava BK, et al. Among authors: gugale sb. Bioorg Med Chem Lett. 2008 Feb 1;18(3):963-8. doi: 10.1016/j.bmcl.2007.12.036. Epub 2007 Dec 23. Bioorg Med Chem Lett. 2008. PMID: 18207393