Winters KJ - Search Results

1

A comparison of the antiplatelet effects of prasugrel and high-dose clopidogrel as assessed by VASP-phosphorylation and light transmission aggregometry.

Jakubowski JA, Payne CD, Li YG, Farid NA, Brandt JT, Small DS, Salazar DE, Winters KJ. Jakubowski JA, et al. Among authors: winters kj. Thromb Haemost. 2008 Jan;99(1):215-22. doi: 10.1160/TH07-09-0555. Thromb Haemost. 2008. PMID: 18217157 Clinical Trial.

2

Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently.

Farid NA, Payne CD, Small DS, Winters KJ, Ernest CS 2nd, Brandt JT, Darstein C, Jakubowski JA, Salazar DE. Farid NA, et al. Among authors: winters kj. Clin Pharmacol Ther. 2007 May;81(5):735-41. doi: 10.1038/sj.clpt.6100139. Epub 2007 Mar 14. Clin Pharmacol Ther. 2007. PMID: 17361128 Clinical Trial.

3

Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel.

Brandt JT, Close SL, Iturria SJ, Payne CD, Farid NA, Ernest CS 2nd, Lachno DR, Salazar D, Winters KJ. Brandt JT, et al. Among authors: winters kj. J Thromb Haemost. 2007 Dec;5(12):2429-36. doi: 10.1111/j.1538-7836.2007.02775.x. Epub 2007 Sep 26. J Thromb Haemost. 2007. PMID: 17900275 Free article.

4

Effect of rifampin on the pharmacokinetics and pharmacodynamics of prasugrel in healthy male subjects.

Farid NA, Jakubowski JA, Payne CD, Li YG, Jin Y, Ernest II CS, Winters KJ, Brandt JT, Salazar DE, Small DS. Farid NA, et al. Among authors: winters kj. Curr Med Res Opin. 2009 Aug;25(8):1821-9. doi: 10.1185/03007990903018360. Curr Med Res Opin. 2009. PMID: 19530977 Clinical Trial.

5

Pharmacokinetics and pharmacodynamics of prasugrel in subjects with moderate liver disease.

Small DS, Farid NA, Li YG, Ernest CS 2nd, Winters KJ, Salazar DE, Payne CD. Small DS, et al. Among authors: winters kj. J Clin Pharm Ther. 2009 Oct;34(5):575-83. doi: 10.1111/j.1365-2710.2009.01067.x. J Clin Pharm Ther. 2009. PMID: 19744013

6

Prasugrel pharmacokinetics and pharmacodynamics in subjects with moderate renal impairment and end-stage renal disease.

Small DS, Wrishko RE, Ernest CS 2nd, Ni L, Winters KJ, Farid NA, Li YG, Brandt JT, Salazar DE, Borel AG, Kles KA, Payne CD. Small DS, et al. Among authors: winters kj. J Clin Pharm Ther. 2009 Oct;34(5):585-94. doi: 10.1111/j.1365-2710.2009.01068.x. J Clin Pharm Ther. 2009. PMID: 19744014

7

The platelet inhibitory effects and pharmacokinetics of prasugrel after administration of loading and maintenance doses in healthy subjects.

Jakubowski JA, Payne CD, Brandt JT, Weerakkody GJ, Farid NA, Small DS, Naganuma H, Li GY, Winters KJ. Jakubowski JA, et al. Among authors: winters kj. J Cardiovasc Pharmacol. 2006 Mar;47(3):377-84. doi: 10.1097/01.fjc.0000210069.47205.c0. J Cardiovasc Pharmacol. 2006. PMID: 16633079 Clinical Trial.

8

A multiple dose study of prasugrel (CS-747), a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy humans.

Jakubowski JA, Matsushima N, Asai F, Naganuma H, Brandt JT, Hirota T, Freestone S, Winters KJ. Jakubowski JA, et al. Among authors: winters kj. Br J Clin Pharmacol. 2007 Apr;63(4):421-30. doi: 10.1111/j.1365-2125.2006.02792.x. Epub 2006 Oct 31. Br J Clin Pharmacol. 2007. PMID: 17076696 Free PMC article. Clinical Trial.

9

A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation.

Brandt JT, Payne CD, Wiviott SD, Weerakkody G, Farid NA, Small DS, Jakubowski JA, Naganuma H, Winters KJ. Brandt JT, et al. Among authors: winters kj. Am Heart J. 2007 Jan;153(1):66.e9-16. doi: 10.1016/j.ahj.2006.10.010. Am Heart J. 2007. PMID: 17174640 Clinical Trial.

10

Dose-dependent inhibition of human platelet aggregation by prasugrel and its interaction with aspirin in healthy subjects.

Jakubowski JA, Payne CD, Weerakkody GJ, Brandt JT, Farid NA, Li YG, Naganuma H, Lachno DR, Winters KJ. Jakubowski JA, et al. Among authors: winters kj. J Cardiovasc Pharmacol. 2007 Mar;49(3):167-73. doi: 10.1097/FJC.0b013e318031301b. J Cardiovasc Pharmacol. 2007. PMID: 17414229 Clinical Trial.

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