Withers SG - Search Results

1

The structure of Clostridium perfringens NanI sialidase and its catalytic intermediates.

Newstead SL, Potter JA, Wilson JC, Xu G, Chien CH, Watts AG, Withers SG, Taylor GL. Newstead SL, et al. Among authors: withers sg. J Biol Chem. 2008 Apr 4;283(14):9080-8. doi: 10.1074/jbc.M710247200. Epub 2008 Jan 24. J Biol Chem. 2008. PMID: 18218621 Free PMC article.

2

Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase.

Watts AG, Oppezzo P, Withers SG, Alzari PM, Buschiazzo A. Watts AG, et al. Among authors: withers sg. J Biol Chem. 2006 Feb 17;281(7):4149-55. doi: 10.1074/jbc.M510677200. Epub 2005 Nov 18. J Biol Chem. 2006. PMID: 16298994 Free article.

3

Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase.

Amaya MF, Watts AG, Damager I, Wehenkel A, Nguyen T, Buschiazzo A, Paris G, Frasch AC, Withers SG, Alzari PM. Amaya MF, et al. Among authors: withers sg. Structure. 2004 May;12(5):775-84. doi: 10.1016/j.str.2004.02.036. Structure. 2004. PMID: 15130470 Free article.

4

Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile.

Watts AG, Damager I, Amaya ML, Buschiazzo A, Alzari P, Frasch AC, Withers SG. Watts AG, et al. Among authors: withers sg. J Am Chem Soc. 2003 Jun 25;125(25):7532-3. doi: 10.1021/ja0344967. J Am Chem Soc. 2003. PMID: 12812490

5

Using substrate engineering to harness enzymatic promiscuity and expand biological catalysis.

Lairson LL, Watts AG, Wakarchuk WW, Withers SG. Lairson LL, et al. Among authors: withers sg. Nat Chem Biol. 2006 Dec;2(12):724-8. doi: 10.1038/nchembio828. Epub 2006 Oct 22. Nat Chem Biol. 2006. PMID: 17057723

6

Glycosynthase-catalysed formation of modified polysaccharide microstructures.

Watts AG, Withers SG. Watts AG, et al. Among authors: withers sg. Biochem J. 2004 Jun 15;380(Pt 3):e9-10. doi: 10.1042/BJ20040633. Biochem J. 2004. PMID: 15182233 Free PMC article.

7

Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity.

Kim JH, Resende R, Wennekes T, Chen HM, Bance N, Buchini S, Watts AG, Pilling P, Streltsov VA, Petric M, Liggins R, Barrett S, McKimm-Breschkin JL, Niikura M, Withers SG. Kim JH, et al. Among authors: withers sg. Science. 2013 Apr 5;340(6128):71-5. doi: 10.1126/science.1232552. Epub 2013 Feb 21. Science. 2013. PMID: 23429702 Free article.

8

Mechanistic investigations of unsaturated glucuronyl hydrolase from Clostridium perfringens.

Jongkees SAK, Yoo H, Withers SG. Jongkees SAK, et al. Among authors: withers sg. J Biol Chem. 2014 Apr 18;289(16):11385-11395. doi: 10.1074/jbc.M113.545293. Epub 2014 Feb 26. J Biol Chem. 2014. PMID: 24573682 Free PMC article.

9

Kinetic and mechanistic analysis of Trypanosoma cruzi trans-sialidase reveals a classical ping-pong mechanism with acid/base catalysis.

Damager I, Buchini S, Amaya MF, Buschiazzo A, Alzari P, Frasch AC, Watts A, Withers SG. Damager I, et al. Among authors: withers sg. Biochemistry. 2008 Mar 18;47(11):3507-12. doi: 10.1021/bi7024832. Epub 2008 Feb 20. Biochemistry. 2008. PMID: 18284211

10

Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog.

Chiu CP, Watts AG, Lairson LL, Gilbert M, Lim D, Wakarchuk WW, Withers SG, Strynadka NC. Chiu CP, et al. Among authors: withers sg. Nat Struct Mol Biol. 2004 Feb;11(2):163-70. doi: 10.1038/nsmb720. Epub 2004 Jan 18. Nat Struct Mol Biol. 2004. PMID: 14730352

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