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Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential.
Appendino G, De Petrocellis L, Trevisani M, Minassi A, Daddario N, Moriello AS, Gazzieri D, Ligresti A, Campi B, Fontana G, Pinna C, Geppetti P, Di Marzo V. Appendino G, et al. J Pharmacol Exp Ther. 2005 Feb;312(2):561-70. doi: 10.1124/jpet.104.074864. Epub 2004 Sep 8. J Pharmacol Exp Ther. 2005. PMID: 15356216
Iodinated N-acylvanillamines: potential "multiple-target" anti-inflammatory agents acting via the inhibition of t-cell activation and antagonism at vanilloid TRPV1 channels.
Márquez N, De Petrocellis L, Caballero FJ, Macho A, Schiano-Moriello A, Minassi A, Appendino G, Muñoz E, Di Marzo V. Márquez N, et al. Among authors: appendino g. Mol Pharmacol. 2006 Apr;69(4):1373-82. doi: 10.1124/mol.105.019786. Epub 2006 Jan 4. Mol Pharmacol. 2006. PMID: 16394182
272 results