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Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors.
Brodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong DE, Pleiss M, McComas C, Hess F, Witter D, Peterson S, Childers M, Goulet M, Liverton N, Hargreaves R, Freedman S, Weisgraber KH, Mahley RW, Huang Y. Brodbeck J, et al. J Biol Chem. 2011 May 13;286(19):17217-26. doi: 10.1074/jbc.M110.217380. Epub 2011 Mar 18. J Biol Chem. 2011. PMID: 21454574 Free PMC article.
Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.
Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. Chen HK, et al. Among authors: brodbeck j. J Biol Chem. 2012 Feb 17;287(8):5253-66. doi: 10.1074/jbc.M111.276162. Epub 2011 Dec 12. J Biol Chem. 2012. PMID: 22158868 Free PMC article.
Tau reduction prevents Abeta-induced defects in axonal transport.
Vossel KA, Zhang K, Brodbeck J, Daub AC, Sharma P, Finkbeiner S, Cui B, Mucke L. Vossel KA, et al. Among authors: brodbeck j. Science. 2010 Oct 8;330(6001):198. doi: 10.1126/science.1194653. Epub 2010 Sep 9. Science. 2010. PMID: 20829454 Free PMC article.
Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells.
Barclay J, Balaguero N, Mione M, Ackerman SL, Letts VA, Brodbeck J, Canti C, Meir A, Page KM, Kusumi K, Perez-Reyes E, Lander ES, Frankel WN, Gardiner RM, Dolphin AC, Rees M. Barclay J, et al. Among authors: brodbeck j. J Neurosci. 2001 Aug 15;21(16):6095-104. doi: 10.1523/JNEUROSCI.21-16-06095.2001. J Neurosci. 2001. PMID: 11487633 Free PMC article.
The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2 delta-2 protein with abnormal function.
Brodbeck J, Davies A, Courtney JM, Meir A, Balaguero N, Canti C, Moss FJ, Page KM, Pratt WS, Hunt SP, Barclay J, Rees M, Dolphin AC. Brodbeck J, et al. J Biol Chem. 2002 Mar 8;277(10):7684-93. doi: 10.1074/jbc.M109404200. Epub 2001 Dec 26. J Biol Chem. 2002. PMID: 11756448 Free article.
Voltage-dependent binding and calcium channel current inhibition by an anti-alpha 1D subunit antibody in rat dorsal root ganglion neurones and guinea-pig myocytes.
Wyatt CN, Campbell V, Brodbeck J, Brice NL, Page KM, Berrow NS, Brickley K, Terracciano CM, Naqvi RU, MacLeod KT, Dolphin AC. Wyatt CN, et al. Among authors: brodbeck j. J Physiol. 1997 Jul 15;502 ( Pt 2)(Pt 2):307-19. doi: 10.1111/j.1469-7793.1997.307bk.x. J Physiol. 1997. PMID: 9263912 Free PMC article.
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